Table 2 Mixed effects model analysis of annual eGFR change by NSAID Exposure.

From: Renal safety of Long-Term Non-steroidal Anti-inflammatory drugs use in patients with ankylosing spondylitis

Model	Variables	Institution	N	Estimated GFR _CKD−EPI		Estimated GFR _MDRD
Model	Variables	Institution	N	β	95% CI	β	95% CI
Model 1	Intercept	AMC	1,618	−0.974	−1.195, −0.753	−1.154	−1.525, −0.784
		SNUBH	995	−0.723	−1.064, −0.381	−0.890	−1.503, −0.277
		Summary	2,613	−0.883	−1.119, −0.648	−1.084	−1.401, −0.767
	NSAID MPR^a	AMC	1,618	−0.007	−0.011, −0.003	−0.016	−0.023, −0.009
		SNUBH	995	−0.008	−0.013, −0.002	−0.013	−0.022, −0.003
		Summary	2,613	−0.007	−0.011, −0.004	−0.015	−0.021, −0.009
Model 2	Intercept	AMC	1,618	−0.978	−1.200, −0.757	−1.170	−1.541, −0.800
		SNUBH	995	−0.712	−1.054, −0.370	−0.868	−1.482, −0.255
		Summary	2,613	−0.878	−1.131, −0.626	−1.090	−1.407, −0.772
	COX-2 inhibitor MPR^a	AMC	1,618	−0.009	−0.016, −0.002	−0.023	−0.035, −0.012
		SNUBH	995	−0.005	−0.012, 0.003	−0.005	−0.018, 0.008
		Summary	2,613	−0.007	−0.012, −0.002	−0.015	−0.033, 0.003
	non-selective COX-2 inhibitor MPR^a	AMC	1,618	−0.006	−0.011, −0.002	−0.014	−0.021, −0.006
		SNUBH	995	−0.010	−0.016, −0.004	−0.017	−0.028, −0.006
		Summary	2,613	−0.008	−0.011, −0.004	−0.015	−0.021, −0.008
Model 3	Intercept	AMC	1,618	−0.793	−1.029, −0.557	−0.751	−1.147, −0.356
		SNUBH	995	−0.433	−0.814, −0.053	−0.424	−1.107, 0.259
		Summary	2,613	−0.645	−0.992, −0.298	−0.669	−1.011, −0.327
	NSAID MPR group (reference: low)
	intermediate	AMC	1,618	−0.294	−0.694, 0.106	−0.507	−1.177, 0.162
		SNUBH	995	−0.591	−1.265, 0.082	−1.210	−2.420, < 0.001
		Summary	2,613	−0.372	−0.715, −0.028	−0.672	−1.258, −0.086
	high	AMC	1,618	−0.507	−0.884, −0.130	−1.251	−1.882, −0.621
		SNUBH	995	−0.625	−1.110, −0.140	−0.909	−1.781, −0.037
		Summary	2,613	−0.551	−0.849, −0.254	−1.134	−1.645, −0.623

eGFR: Estimated Glomerular Filtration Rate; CKD-EPI: Chronic Kidney Disease Epidemiology Collaboration; MDRD: Modification of diet in renal disease; MPR: Medication Possession Ratio; COX-2: cyclooxygenase 2; ^aIn the multivariable model, continuous variables such as baseline eGFR, age, MPR, and average CRP were centered by subtracting their mean values.

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Table 2 Mixed effects model analysis of annual eGFR change by NSAID Exposure.

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