Table 4 Mixed effects model analysis of eGFR change from baseline by cumulative NSAIDs exposure according to MPR groupa.
Years | Variables | Source | N | Estimated GFR CKD−EPI | Estimated GFR MDRD | ||
|---|---|---|---|---|---|---|---|
Estimate | 95% CI | Estimate | 95% CI | ||||
3 | Intermediate | AMC | 1,224 | −0.088 | −1.171, 0.996 | −0.318 | −2.059, 1.424 |
SNUBH | 679 | 0.061 | −1.800, 1.923 | 1.017 | −2.070, 4.104 | ||
Summary | 1,903 | −0.050 | −0.987, 0.886 | 0.005 | −1.512, 1.522 | ||
High | AMC | 1,224 | −0.324 | −1.557, 0.909 | −0.803 | −2.790, 1.184 | |
SNUBH | 679 | 1.516 | −0.123, 3.155 | 1.832 | −0.903, 4.566 | ||
Summary | 1,903 | 0.514 | −1.283, 2.310 | 0.340 | −2.219, 2.899 | ||
6 | Intermediate | AMC | 1,224 | 0.304 | −0.899, 1.507 | −0.149 | −2.078, 1.780 |
SNUBH | 679 | −0.264 | −2.496, 1.969 | 0.851 | −2.817, 4.519 | ||
Summary | 1,903 | 0.176 | −0.883, 1.235 | 0.068 | −1.640, 1.775 | ||
High | AMC | 1,224 | −0.721 | −2.246, 0.803 | −0.846 | −3.295, 1.604 | |
SNUBH | 679 | −1.437 | −3.717, 0.843 | −1.456 | −5.224, 2.312 | ||
Summary | 1,903 | −0.942 | −2.210, 0.325 | −1.027 | −3.081, 1.027 | ||
9 | Intermediate | AMC | 1,224 | 0.326 | −1.055, 1.707 | 1.088 | −1.124, 3.300 |
SNUBH | 679 | −4.055 | −7.326, −0.785 | −5.403 | −10.753, −0.054 | ||
Summary | 1,903 | −1.603 | −5.867, 2.660 | −1.682 | −7.975, 4.611 | ||
High | AMC | 1,224 | −1.063 | −3.074, 0.948 | −1.756 | −4.979, 1.468 | |
SNUBH | 679 | −4.338 | −7.608, −1.069 | −4.006 | −9.379, 1.368 | ||
Summary | 1,903 | −2.436 | −5.604, 0.731 | −2.351 | −5.116, 0.413 | ||
12 | Intermediate | AMC | 1,224 | 0.800 | −0.905, 2.506 | 3.828 | 1.099, 6.557 |
SNUBH | 679 | −3.704 | −8.279, 0.870 | −8.561 | −16.027, −1.094 | ||
Summary | 1,903 | −0.931 | −5.226, 3.364 | −1.859 | −13.959, 10.241 | ||
High | AMC | 1,224 | 1.200 | −1.373, 3.772 | 3.241 | −0.878, 7.359 | |
SNUBH | 679 | −2.764 | −11.088, 5.561 | 14.453 | 0.855, 28.050 | ||
Summary | 1,903 | 0.854 | −1.604, 3.312 | 6.897 | −3.405, 17.199 | ||
15 | Intermediate | AMC | 1,224 | 1.373 | −1.000, 3.746 | 2.078 | −1.715, 5.871 |
SNUBH | 679 | −2.594 | −7.853, 2.666 | −7.955 | −16.535, 0.626 | ||
Summary | 1,903 | 0.113 | −3.507, 3.732 | −2.170 | −11.886, 7.546 | ||
High | AMC | 1,224 | −1.872 | −5.666, 1.923 | −4.682 | −10.747, 1.384 | |
SNUBH | 679 | 1.516 | −0.123, 3.155 | 1.832 | −0.903, 4.566 | ||
Summary | 1,903 | 0.272 | −2.929, 3.473 | −0.839 | −7.118, 5.440 | ||
18 | Intermediate | AMC | 1,224 | −0.738 | −4.223, 2.747 | −1.619 | −7.187, 3.949 |
High | AMC | 1,224 | −9.618 | −15.298, −3.938 | −11.989 | −21.065, −2.914 | |
