Fig. 5
From: Chemotherapy treatment alters DNA methylation patterns in the prefrontal cortex of female rat brain
Changes in histone acetyl transferase and histone deacetylase activity following AC chemotherapy regimen in female rat PFC. (a) The bar graph represents the HAT activity level change between saline-treated and chemotherapy-treated animal tissue (p-value: 0.31). (b) A bar graph representation of the HDAC activity level change between saline-treated and chemotherapy-treated animal tissue (p-value: 0.0143). (c) Bar graph representing changes in the CBP gene expression level between saline-treated and chemotherapy-treated animal tissues (p-value: 0.2063). (d) Bar graph representation of the change in CREB gene expression level between saline treated and chemotherapy-treated animal tissue (p-value: 0.0286). Error bars represent the standard error of the mean. This experiment used four saline-treated animal samples and five chemotherapy-treated animal samples.
