Fig. 1 | Scientific Reports

Fig. 1

From: NFATc1 facilitates hepatocellular carcinoma progression by regulating the senescence-associated secretory phenotype

Fig. 1

NFATc1 is upregulated in HCC patients and correlates with poor prognosis. (a) RT-qPCR analysis of NFATc1 expression in paired tumor (T) and adjacent non-tumor (A) tissues (n = 12). (b) Representative Western blot images and quantification of NFATc1 protein levels in HCC samples (n = 12). (c) NFATc1 localization assessed by nuclear and cytoplasmic protein fractionation (n = 4). (d) Representative IHC images and quantitative IHC analysis of NFATc1 expression in HCC tissue microarrays (n = 289). (e) Representative IHC images illustrating varying staining intensities: none, weak, moderate, strong. (f) Kaplan-Meier survival analysis of time to progression and overall survival in HCC patients, stratified by NFATc1 expression (n = 289). Statistical analysis: Student’s t-test for two-group comparisons, Chi-square for categorical variables, Kaplan-Meier for survival, with Benjamini-Hochberg FDR correction. *p < 0.05, **p < 0.01, ****p < 0.0001.

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