Table 3 Intercorrelation matrix between serum biomarkers and the non-motor (nM) experiences of daily life (nM-EDL), mood and chronic fatigue (CFS) symptoms.

Variables	Total nM-EDL	MOOD	CFS	MOOD + CSF
Magnesium	0.079(0.372)	0.067(0.450)	0.102(0.250)	0.085(0.339)
Calcium	-0.334(< 0.001)	-0.383(< 0.001)	-0.314(< 0.001)	-0.344(< 0.001)
HOMA2%S	-0.314(< 0.001)	-0.289(0.001)	-0.326(< 0.001)	-0.309(< 0.001)
HOMA2IR	0.374(< 0.001)	0.339(< 0.001)	0.382(< 0.001)	0.363(< 0.001)
Copper	0.084(0.341)	0.118(0.182)	0.078(0.378)	0.087(0.325)
Zinc	-0.016(0.859)	0.012(0.897)	-0.015(0.864)	-0.007(0.934)
NSE	0.611(< 0.001)	0.536(< 0.001)	0.602(< 0.001)	0.583(< 0.001)
S100B	0.496(< 0.001)	0.474(< 0.001)	0.500(< 0.001)	0.495(< 0.001)
pTau217	0.291(0.001)	0.250(0.004)	0.283(0.001)	0.269(0.002)
GFAP	0.275(0.002)	0.239(0.006)	0.295(0.001)	0.271(0.002)
IL-6	0.081(0.362)	0.041(0.645)	0.100(0.258)	0.070(0.431)
IL-10	0.576(< 0.001)	0.494(< 0.001)	0.581(< 0.001)	0.559(< 0.001)

Each cell shows the Pearson correlation coefficient (p-value). HOMA2IR: Homeostatic Model Assessment of Insulin Resistance (HOMA2) insulin resistance, HOMA2%S: (HOMA2) insulin sensitivity, NSE: neuron-specific enolase, GFAP: Glial fibrillary acidic protein, IL-6: interleukin (IL)-6, pTau217: phosphorylated tubulin associated unit, S100B: S100 calcium-binding protein B, MOOD: mood symptoms of the nM-EDL, CFS: CFS symptoms of the nm-EDL, MOOD + CFS: sum of all MOOD and CSF symptoms.

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