Table 4 Results of multiple regression analysis with physio-affective symptom domains as dependent variables and biomarkers as explanatory variables in all subjects included in the study.

From: Affective and chronic fatigue symptoms are associated with serum neuronal damage markers in Parkinson’s disease

Dependent Variables

Explanatory Variables

β

t

P

F model

df

p

R2

#1. Total nM-EDL

Model #1

38.97

4/125

< 0.001

0.555

NSE

0.352

4.93

< 0.001

IL-10

0.326

4.66

< 0.001

HOMA2IR

0.217

3.52

0.001

Calcium

-0.212

-3.49

0.001

#2. MOOD

Model #2

   

23.61

5/124

< 0.001

0.488

NSE

0.255

3.19

0.002

Calcium

-0.278

-4.25

< 0.001

S100B

0.174

2.21

0.029

IL-10

0.222

2.86

0.005

HOMA2IR

0.154

2.22

0.028

#3. CFS

Model #3

   

37.92

4/125

< 0.001

0.548

NSE

0.337

4.69

< 0.001

IL-10

0.340

4.82

< 0.001

HOMA2IR

0.229

3.68

< 0.001

Calcium

-0.192

-3.13

0.002

#4. MOOD + CFS

Model #4

   

29.18

5/124

< 0.001

0.525

NSE

0.283

3.73

< 0.001

IL-10

0.286

3.89

< 0.001

Calcium

-0.226

-3.65

< 0.001

HOMA2IR

0.173

2.63

0.010

S100B

0.152

2.05

0.043

  1. β: standardized regression coefficient, df: degree of freedom, F: value of F-test, R22: the coefficient of determination.
  2. HOMA2IR: Homeostatic Model Assessment of Insulin Resistance (HOMA2) insulin resistance, NSE: neuron-specific enolase, S100B: S100 calcium-binding protein B, IL: interleukin, nM-EDL: non-Motor aspects of Experiences Daily Living, MOOD: mood symptoms of the nM-EDL; CFS: chronic fatigue syndrome (CFS) symptoms of the nm-EDL; MOOD + CFS: sum of all MOOD and CSF symptoms.
Back to article page