Table 5 Results of multiple regression analysis with the physio-affective symptom domains as dependent variables and biomarkers as explanatory variables; regressions are conducted in the restricted group of patients with parkinson’s disease.

From: Affective and chronic fatigue symptoms are associated with serum neuronal damage markers in Parkinson’s disease

Dependent Variables

Explanatory Variables

β

t

P

F model

df

p

R2

#1. Total nM-EDL

Model

16.25

2/67

< 0.001

0.327

IL-10

0.346

3.09

0.003

NSE

0.326

2.91

0.005

#2. MOOD

Model

6.77

1/68

0.011

0.090

IL-10

0.301

2.60

0.011

#3. CFS

Model

15.68

2/67

< 0.001

0.319

IL-10

0.360

3.20

0.002

NSE

0.303

2.69

0.009

#4. MOOD + CSF

Model

11.93

2/67

< 0.001

0.263

IL-10

0.347

2.96

0.004

NSE

0.253

2.16

0.035

#5. Total m-EDL

Model

11.95

2/67

< 0.001

0.263

GFAP

0.358

3.32

0.001

HOMA2IR

0.290

2.68

0.009

  1. nM-EDL: non-motor aspects of Experiences Daily Living, MOOD: mood symptoms of the nM-EDL; CFS: chronic fatigue syndrome (CFS) symptoms of the nm-EDL; MOOD + CFS: sum of all MOOD and CSF symptoms, m-EDL: Motor aspects of Experiences Daily Living, HOMA2IR: Homeostatic Model Assessment of Insulin Resistance (HOMA2) insulin resistance, NSE: neuron-specific enolase, GFAP: Glial fibrillary acidic protein, IL: interleukin.
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