Table 4 POMS2 TMD (total mood disturbance) scores and subscores during intake period.
Placebo | YRC3780 | |||||
|---|---|---|---|---|---|---|
Beforethe U-K test | Before the U-K test | |||||
Baseline (n = 53) | Week 4 (n = 53) | Week 8 (n = 53) | Baseline (n = 55)* | Week 4 (n = 55)* | Week 8 (n = 54) | |
TMD score | 56.9 ± 9.2 | 52.9 ± 9.3 | 50.3 ± 9.1 | 56.8 ± 11.2 | 52.1 ± 11.1 | 50.7 ± 10.7 |
Change in score from baseline (points) | — | –4.0 ± 9.2 | –6.6 ± 7.8 | — | –4.7 ± 8.8 | –5.9 ± 9.0 |
Percentage change from baseline (%) | — | –5.9 ± 16.0 | –10.8 ± 12.5 | — | –7.5 ± 13.8 | –9.5 ± 13.9 |
AH score | 54.7 ± 10.0 | 52.7 ± 10.9 | 50.3 ± 11.4 | 53.2 ± 11.6 | 49.7 ± 9.6 | 48.9 ± 10.8 |
Change in score from baseline (points) | — | –2.0 ± 10.0 | –4.4 ± 10.7 | — | –3.5 ± 10.1 | –4.3 ± 10.3 |
Percentage change from baseline (%) | — | –2.3 ± 18.4 | –6.8 ± 19.7 | — | –4.8 ± 16.0 | –6.6 ± 16.2 |
CB score | 57.7 ± 11.7 | 54.3 ± 11.5 | 50.4 ± 9.7 | 58.6 ± 12.0 | 54.2 ± 12.1 | 52.2 ± 11.2 |
Change in score from baseline (points) | — | –3.4 ± 11.8 | –7.3 ± 8.1 | — | –4.4 ± 9.6 | –6.2 ± 9.8 |
Percentage change from baseline (%) | — | –3.9 ± 22.6 | –11.4 ± 12.7 | — | –6.5 ± 15.0 | –9.3 ± 14.9 |
DD score | 55.8 ± 10.4 | 52.3 ± 9.3 | 49.8 ± 8.1 | 55.8 ± 11.9 | 53.0 ± 10.6 | 50.8 ± 10.4 |
Change in score from baseline (points) | — | –3.5 ± 9.6 | –6.0 ± 8.6 | — | –2.8 ± 7.6 | –5.0 ± 9.1 |
Percentage change from baseline (%) | — | –5.0 ± 15.1 | –9.4 ± 13.4 | — | –4.1 ± 11.7 | –7.6 ± 13.3 |
FI score | 56.1 ± 9.3 | 52.5 ± 9.9 | 50.8 ± 9.9 | 56.0 ± 11.1 | 51.5 ± 10.4 | 51.4 ± 10.5 |
Change in score from baseline (points) | — | –3.6 ± 7.9 | –5.3 ± 8.3 | — | –4.5 ± 9.0 | –4.3 ± 9.4 |
Percentage change from baseline (%) | — | –5.6 ± 14.3 | –8.6 ± 14.4 | — | –6.7 ± 15.6 | –6.4 ± 15.8 |
TA score | 56.1 ± 9.4 | 50.7 ± 8.7 | 49.7 ± 8.3 | 57.0 ± 11.0 | 51.6 ± 10.9 | 51.1 ± 10.7 |
Change in score from baseline (points) | — | –5.4 ± 10.7 | –6.4 ± 8.5 | — | –5.4 ± 9.3 | –5.7 ± 10.1 |
Percentage change from baseline (%) | — | –7.8 ± 18.9 | –10.2 ± 15.0 | — | –8.5 ± 15.3 | –8.8 ± 15.8 |
VA score | 47.0 ± 7.9 | 47.9 ± 10.8 | 49.1 ± 10.1 | 46.8 ± 9.1 | 49.7 ± 9.9 | 50.0 ± 9.9 |
Change in score from baseline (points) | — | 1.0 ± 8.5 | 2.2 ± 7.6 | — | 2.9 ± 7.6 | 2.9 ± 6.4 |
Percentage change from baseline (%) | — | 2.6 ± 18.4 | 5.1 ± 16.1 | — | 7.2 ± 16.1 | 7.0 ± 13.7 |
F score | 50.7 ± 8.5 | 49.3 ± 11.2 | 49.9 ± 10.9 | 47.6 ± 11.3 | 47.9 ± 11.2 | 48.1 ± 8.8 |
Change in score from baseline (points) | — | –1.4 ± 8.1 | –0.7 ± 8.1 | — | 0.3 ± 8.1 | 0.5 ± 6.2 |
Percentage change from baseline (%) | — | –2.5 ± 16.0 | –1.1 ± 16.4 | — | 2.2 ± 18.7 | 3.3 ± 15.0 |
