Fig. 4 | Scientific Reports

Fig. 4

From: Exercise ameliorates nonalcoholic fatty liver disease by reducing the IGFBP5 to IGF1 ratio to activate AMPK pathway

Fig. 4

Exercise activated IRS1/Akt/AMPK pathway due to reduce serum IGFBP5/total IGF1 ratio. (A). Protein levels of IGFBP5, IGF1, IGF1R, IRS1, p-IRS1 (Ser307), p-IRS1 (Tyr612), Akt, p-Akt (Ser473), AMPKα and p-AMPKα (Thr183/172) in mouse livers were assayed by western blot. (B). Protein expression results are presented as the mean ± SEM, n = 6 per group. ns P > 0.05, ** P < 0.01 and ***P < 0.001.

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