Fig. 6
Manhattan plot of transcriptome-wide association study (TWAS) of AAA using FUSION49. The horizontal red dashed line indicates the transcriptome-wide significance threshold (adjusted p-value = 2.5 × 10−6), while the horizontal blue dashed line represents the suggestive significance threshold (adjusted p-value = 6.25 × 10−6). Each point shows a transcript tested for association with expression imputation from the METAL results. The x-axis displays the genomic coordination of the genes, and the y-axis illustrates the negative logarithm of the transcriptome-wide association adjusted p-value. The adjusted p-value was obtained using the Bonferroni correction method. Genes with adjusted p-values below the suggestive significance threshold (i.e., above the corresponding –log₁₀(p-value) line) are labelled with their gene names. The plot was visualized using qqman package in R46.
