Table 2 Gene-set enrichment analysis of the mapped genes using MAGMA.
Gene set | Number of genes | Beta | Beta STD | SE | p-value | Adjusted p-value |
|---|---|---|---|---|---|---|
Reactome: LDL remodeling | 6 | 1.645 | 0.029 | 0.324 | 1.943e-07 | 0.003 |
GO-BP: Positive regulation of protein catabolic process in the vacuole | 5 | 1.412 | 0.023 | 0.304 | 1.673e-06 | 0.028 |
WP: Familial hyperlipidemia type 5 | 14 | 0.971 | 0.026 | 0.220 | 5.081e-06 | 0.086 |
GO-BP: Regulation of phospholipid catabolic process | 7 | 1.418 | 0.027 | 0.327 | 7.520e-06 | 0.128 |
WP: Statin inhibition of cholesterol production | 29 | 0.668 | 0.026 | 0.158 | 1.158e-05 | 0.197 |
WP: Lipid particles composition | 10 | 1.112 | 0.025 | 0.265 | 1.341e-05 | 0.228 |
Reactome: Downregulation of SMAD2, 3, and SMAD4 transcriptional activity | 29 | 0.627 | 0.024 | 0.156 | 2.841e-05 | 0.483 |
GO-BP: Intracellular receptor signaling pathway | 279 | 0.193 | 0.023 | 0.049 | 3.536e-05 | 0.601 |
GO-BP: SMAP protein signal transduction | 79 | 0.373 | 0.024 | 0.094 | 3.878e-05 | 0.659 |
WP: Familial hyperlipidemia type 3 | 13 | 0.854 | 0.022 | 0.217 | 4.180e-05 | 0.710 |
