Table 2 Univariable and multivariable Cox analysis for predicting overall survival in training cohort.

From: Development, verification, and comparison of a risk stratification model to identify potential population benefiting from chemotherapy in non-metastatic male breast cancer

Training cohort (N = 1961)

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Age

 < 75

Reference

 

Reference

 

 ≥ 75

3.283 (2.858–3.772)

< 0.001

2.860 (2.474–3.307)

< 0.001

Race

 White

Reference

 

Reference

 

 Black

1.592 (1.103–1.926)

< 0.001

1.451 (1.044–2.010)

0.042

 Asian and other

0.589 (0.392–0.884)

0.011

0.712 (0.472–1.074)

0.055

Grade

 1

Reference

 

Reference

 

 2

1.336 (1.089–1.639)

0.005

1.114 (0.903–1.374)

0.314

 3

1.948 (1.575–2.409)

< 0.001

1.353 (1.083–1.691)

0.008

Surgery

 BCS

Reference

 

Reference

 

 Mastectomy

0.891 (0.711–1.116)

0.314

1.080 (0.858–1.360)

0.514

 No

3.561 (2.523–5.026)

< 0.001

2.556 (1.773–3.686)

< 0.001

Primary

 No

Reference

 

Reference

 

 Yes

0.621 (0.537–0.717)

< 0.001

0.764 (0.658–0.886)

< 0.001

Marital status

 Married

Reference

 

Reference

 

 Unmarried

1.540 (1.337–1.773)

< 0.001

1.360 (1.177–1.572)

< 0.001

Stage

 I

Reference

 

Reference

 

 II

1.735 (1.497–2.010)

< 0.001

0.851 (0.625–1.160)

0.308

 III

2.906 (2.383–3.544)

< 0.001

0.775 (0.431–1.394)

0.394

T stage

 T1

Reference

 

Reference

 

 T2

1.769 (1.535–2.039)

< 0.001

1.691 (1.295–2.208)

< 0.001

 T3

3.791 (2.967–4.843)

< 0.001

2.583 (1.579–4.226)

< 0.001

 T4

2.719 (1.785–4.141)

< 0.001

2.661 (1.622–4.367)

< 0.001

N stage

 N0

Reference

 

Reference

 

 N1

1.850 (1.393–2.458)

< 0.001

1.461 (0.879–2.429)

0.143

 N2

1.610 (1.373–1.889)

< 0.001

1.415 (1.145–1.749)

0.001

 N3

2.248 (1.582–3.194)

< 0.001

1.751 (1.039–2.953)

0.035

  1. Significant values are in [bold].
Back to article page