Fig. 5 | Scientific Reports

Fig. 5

From: Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrest

Fig. 5

15a and 15d induced HepG2 cell cycle arrest. (A) The cell cycle of HepG2 cells treated with 15a, 15d, and SAHA for 24 h at the indicated concentrations was examined by flow cytometry analyses. (B) The statistical result of (A). (C) HepG2 cells treated with 15a, 15d, and SAHA for 24 h at the indicated concentrations, the expression of CDK4 and Cyclin D1 protein levels were examined by Western blot analysis, and β-actin was detected as the endogenous loading control, accordingly. (D) The statistical result of (C). The data are expressed as means ± SD of three separate experiments. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control.

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