Table 2 IC50 values of compounds 15a–15n against HDAC1.

From: Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrest

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Compounds

R2

IC50(nM)

15a

H

1.1

15b

2′-CH3

1.3

15c

3′-CH3

1.9

15d

4′-CH3

0.8

15e

4′-OCH3

1.6

15f

2′-F

1.7

15g

3′-F

1.2

15h

4′-F

1.3

15i

2′-Cl

2.1

15j

3′-Cl

1.7

15k

4′-Cl

1.0

15l

2′-Br

1.3

15m

3′-Br

1.5

15n

4′-Br

1.0

SAHA

 

10.7

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