Table 4 In vitro selectivity profile of selected HDACis.
Classes | IC50 (nM) for HDACs | ||||||
|---|---|---|---|---|---|---|---|
Class I | Class II | Class IV | |||||
Isoforms | 1 | 4 | 5 | 7 | 9 | 6 | 11 |
8h | 0.9 | > 10,000 | > 10,000 | > 10,000 | > 10,000 | 3.5 | > 10,000 |
15a | 1.1 | > 10,000 | > 10,000 | > 10,000 | > 10,000 | 2.7 | > 10,000 |
15d | 0.8 | > 10,000 | > 10,000 | > 10,000 | > 10,000 | 2.5 | > 10,000 |
15n | 1.0 | > 10,000 | > 10,000 | > 10,000 | > 10,000 | 3.2 | > 10,000 |
SAHA | 10.7 | ND | ND | ND | ND | 20.4 | > 10,000 |
