Table 4 Summary of main Pharmacokinetic parameters of two kinds of resveratrol, T1 and T2.
Parameter Mean ± SD (CV%) | Free (unconjugated) resveratrol | Resveratrol-3-O-β-D-glucuronide | Resveratrol-4-O-β-D-glucuronide | Resveratrol-3-O-D-sulfate | Total resveratrol | |||||
|---|---|---|---|---|---|---|---|---|---|---|
T1 | T2 | T1 | T2 | T1 | T2 | T1 | T2 | T1 | T2 | |
Cmax (ng /mL) | 1271.79 ± 496.4 (36.91) | 44.14 ± 19.05*** (43.16) | 38223.78 ± 8292.32 (21.69) | 5846.66 ± 2557.72*** (43.75) | 13097.08 ± 4180.65 (31.92) | 1150.35 ± 570.18*** (49.57) | 8614.58 ± 1930.19 (22.41) | 1387.1 ± 663.51*** (47.83) | 16088.16 ± 3077.98 (19.13) | 3321.63 ± 1438.83*** (43.32) |
AUC0 − t(h*ng /mL) | 706.77 ± 311.24 (44.04) | 109.7 ± 45.43*** (41.41) | 64186.12 ± 16088.99 (25.07) | 30601.4 ± 6919.72***.(22.61) | 17817.22 ± 5973.99.(33.53) | 5206.37 ± 1672.56*** (32.13) | 16111.73 ± 3829.81 (23.77) | 7688.87 ± 2410.68*** (31.35) | 29538.56 ± 8329.03 (28.2) | 17380.65 ± 3865.14*** (22.24) |
AUC0−∞( h*ng /mL) | 777.29 ± 275.48 (35.44) | 149.85 ± 51.3*** (34.24) | 69910.74 ± 18308.12 (26.19) | 33774.37 ± 7907.3*** (23.41) | 18800.36 ± 6356.74 (33.81) | 5820.45 ± 1866.42*** (32.07) | 17850.26 ± 4808.22 (26.94) | 8602.78 ± 2741.52*** (31.87) | 31530.9 ± 9097.86 (28.85) | 19216.5 ± 4318.9*** (22.47) |
Tmax (h) | 0.5 (0.25,1.75) | 1.75** (0.25,5.00) | 0.75 (0.75,1.75) | 2.00** (0.50,5.00) | 0.75 (0.75,1.75) | 2.00*** (1.00,5.00) | 0.75 (0.75,2.00) | 3.00*** (1.00,5.00) | 0.75 (0.75,1.75) | 2.00** (0.75,5.00) |
t1/2 (h) | 4.56 ± 5.9 (129.44) | 5.65 ± 5.36 (94.95) | 7.64 ± 4.72 (61.79) | 7.14 ± 3.22 (45.11) | 6.63 ± 4.02 (60.64) | 7.19 ± 4.93 (68.51) | 7.44 ± 4.52 (60.77) | 6.83 ± 4.59 (67.12) | 7.12 ± 4.35 (61.11) | 7.15 ± 2.49 (34.79) |
