Fig. 6 | Scientific Reports

Fig. 6

From: Simvastatin inhibits the immunosuppressive effects of endometrial cancer-associated mesenchymal stem cells through TGF-β2/SMAD2/3 signaling and reduces tumor growth

Fig. 6

Animal study- humanized mouse model. Tumor size was calculated by length x width x width/2 (mm3). (A) HEC-1 A + CaMSCs (C) RL95-2 + CaMSCs. The mice were divided into (i) untreated (n = 5 (HEC-1 A) or 4 (RL95-2)), (ii) treated with NK-92 cells (n = 4), (iii) simvastatin (1 mg/kg) (n = 4), and (iv) combination treatment with NK-92 cells and simvastatin (n = 4). Gross pictures of xenograft tumors formed by (B) HEC-1 A + CaMSCs and (D) RL95-2 + CaMSCs in various groups. *p < 0.05, **p < 0.01, ***p < 0.001.

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