Fig. 9 | Scientific Reports

Fig. 9

From: Association of Post Kala-Azar Dermal Leishmaniasis pathogenesis with prolonged sunlight (ultraviolet radiations) exposure in VL endemic population of Bihar

Fig. 9The alternative text for this image may have been generated using AI.

Secretion of cytokines in THP-1 cells under UVB + 5 m irradiation for varying durations for day 3 versus day 5 from first passages (G1) to second/subsequent passages (G2). A IL-10 concentration increased significantly from 3 to 5 days of UVB + 5 m irradiation in G2 compared to the UVB-negative control group (A1, A2). B Conversely, IL-12 concentration decreased under the same conditions, with reduced levels observed at both time points and even in G2 (B1, B2). C Similarly, IFN-γ Receptor concentration was also down-regulated in THP-1 cells exposed to UVB + 5 m irradiation, with comparable reductions seen after 3 and 5 days in both G1& G2 passages (C1, C2). Data are representative of three independent experiments. The statistical analysis shows as p-values p < 0.05 (*) or p < 0.005 (**) are significant, while p > 0.05 (ns) as non-significant.

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