Table 3 Meta-analysis of the association between the IL-37 polymorphism and SLE.
From: Association of IL-37 levels and genetic variants with systemic lupus erythematosus: a meta-analysis
Polymorphism | Population | No. of studies | Test of association | Test of heterogeneity | ||||
|---|---|---|---|---|---|---|---|---|
OR | 95% CI | p-val | Model | p-val | I2 | |||
Rs3811047 A vs. G | Overall | 4 | 1.178 | 0.549–2.526 | 0.675 | R | < 0.001 | 93.8 |
Arab | 3 | 1.393 | 0.568–3.419 | 0.469 | R | < 0.001 | 92.8 | |
Asian | 1 | 0.725 | 0.525-1.000 | 0.050 | NA | NA | NA | |
AA vs. AG + GG (Recessive) | Overall | 4 | 1.462 | 0.465–4.592 | 0.516 | R | < 0.001 | 84.7 |
Arab | 3 | 1.597 | 0.357–4.147 | 0.541 | R | < 0.001 | 87.6 | |
Asian | 1 | 1.007 | 0.411–2.470 | 0.987 | NA | NA | NA | |
AA + AG vs. GG (Dominant) | Overall | 4 | 1.148 | 0.514–2.562 | 0.777 | R | < 0.001 | 90.8 |
Arab | 3 | 1.432 | 0.607–3.373 | 0.413 | R | < 0.001 | 85.8 | |
Asian | 1 | 0.649 | 0.448–0.941 | 0.023 | NA | NA | NA | |
AA vs. GG | Overall | 4 | 1.457 | 0.384–5.527 | 0.580 | R | < 0.001 | 88.0 |
Arab | 3 | 1.680 | 0.307–9.193 | 0.550 | R | < 0.001 | 89.5 | |
Asian | 1 | 0.883 | 0.358–2.180 | 0.788 | NA | NA | NA | |
AG vs. GG | Overall | 4 | 1.457 | 0.384–5.527 | 0.580 | R | < 0.001 | 88.0 |
Arab | 3 | 1.680 | 0.307–9.193 | 0.550 | R | < 0.001 | 89.5 | |
Asian | 1 | 0.883 | 0.358–2.180 | 0.788 | NA | NA | NA | |
