Fig. 1
From: Curcumin mitigates high glucose-induced cardiac oxidative stress via Notch1 pathway activation
CUR increased viability of myocardial cells subjected to HG injury. (A) Rat myocardial cells were incubated with CUR (concentration gradient 5, 10, 20, 40 µM, respectively). (B) The HG group decreased the viability of myocardial cells, whereas HG + CUR treatment increased the cell viability, while treatment of the Notch1 inhibitor DAPT abolished the effects of CUR on cell viability. (C) Cell viability was determined using the TransDetect™ Cell Counting Kit (CCK)-8 assay at varying concentrations of CUR at different timepoints (12, 24, 36, and 48 h).**P < 0.01, ΔΔP < 0.01, and ##P < 0.01 versus 20 µM CUR group at 12, 24, 36, 48 h, respectively (A). **P < 0.01 HG group vs. HG + CUR group, *P < 0.05 HG group vs. HG + DAPT group, **P < 0.01 HG + CUR group vs. HG + CUR + DAPT group (B). Data are expressed as the mean ± SD, n = 3.
