Table 2 Associations between serum gamma-glutamyl transpeptidase level and risk of lung cancer.

From: Circulating gamma-glutamyl transpeptidase, systemic inflammation biomarkers and risk of lung cancer in the UK biobank prospective cohort study

Variables

Crude model

Model 1

Model 2

HR(95%CI)

P value

HR(95%CI)

P value

HR(95%CI)

P value

GGT a

1.030 [1.025, 1.034]

<0.001

1.026 [1.022, 1.031]

<0.001

1.018 [1.013, 1.023]

<0.001

GGT b

Ā ā‰¤ 26.30 U/L

1(reference)

Ā 

1(reference)

Ā 

1(reference)

Ā 

Ā >26.30 U/L

1.572 [1.470, 1.681]

<0.001

1.390 [1.296, 1.491]

<0.001

1.206 [1.121, 1.297]

<0.001

GGT C

Ā Q1

1(reference)

Ā 

1(reference)

Ā 

1(reference)

Ā 

Ā Q2

1.580 [1.419, 1.758]

<0.001

1.337 [1.200, 1.490]

<0.001

1.226 [1.099, 1.367]

<0.001

Ā Q3

1.852 [1.669, 2.056]

<0.001

1.506 [1.352, 1.677]

<0.001

1.300 [1.165, 1.451]

<0.001

Ā Q4

2.196 [1.984, 2.430]

<0.001

1.820 [1.637, 2.024]

<0.001

1.451 [1.299, 1.621]

<0.001

P trend

Ā 

<0.001

Ā 

<0.001

Ā 

<0.001

  1. GGT gamma-glutamyl transpeptidase. aGGT as continuous variable per 10U/L. bGGT as dichotomous variable by median.cGGT as quartile variable. Crude Model: no adjustment. Adjusted Model 1: adjusted for age at recruitment, sex. Adjusted Model 2: adjusted for age at recruitment, sex, education level, Townsend deprivation index, body mass index, smoking status, family history of lung cancer, alcohol intake frequency, liver disease status at the baseline.
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