Table 3 Associations between inflammation biomarkers and risk of lung cancer.
Inflammation biomarkers | HR (95% CI) for per | HR (95% CI) according to biomarkers concentration in median | HR (95% CI) according to inflammation biomarkers concentration in quartiles | |||||
|---|---|---|---|---|---|---|---|---|
increase | ||||||||
Increase | HR (95% CI) | Q1 | Q2 | Q3 | Q4 | P trend | ||
Lymphocyte count | 1*10^9/L | 1.065 [1.050, 1.082] | 1.200 [1.119, 1.287] | 1(reference) | 1.088 [0.979, 1.209] | 1.148 [1.037, 1.270] | 1.364 [1.236, 1.506] | <ā0.001 |
Neutrophill count | 1*10^9/L | 1.169 [1.148, 1.190] | 1.524 [1.416, 1.639] | 1(reference) | 1.081 [0.961, 1.217] | 1.299 [1.162, 1.453] | 1.854 [1.670, 2.058] | <ā0.001 |
Platelet count | 1*10^9/L | 1.002 [1.001, 1.002] | 1.258 [1.176, 1.346] | 1(reference) | 1.012 [0.918, 1.116] | 1.164 [1.058, 1.281] | 1.373 [1.250, 1.507] | <ā0.001 |
NLR | 1 unit | 1.039 [1.030, 1.047] | 1.203 [1.125, 1.285] | 1(reference) | 1.004 [0.909, 1.109] | 1.127 [1.022, 1.242] | 1.285 [1.168, 1.413] | <ā0.001 |
PLR | 100 unit | 1.016 [0.991, 1.041] | 0.952 [0.889, 1.019] | 1(reference) | 0.939 [0.860, 1.025] | 0.879 [0.801, 0.965] | 0.976 [0.889, 1.071] | 0.046 |
SII | 100 *10^9/L | 1.017 [1.014, 1.020] | 1.259 [1.178, 1.345] | 1(reference) | 1.067 [0.965, 1.180] | 1.144 [1.037, 1.262] | 1.451 [1.323, 1.592] | <ā0.001 |
White blood cell count | 1*10^9/L | 1.077 [1.070, 1.084] | 1.589 [1.475, 1.713] | 1(reference) | 1.136 [1.005, 1.284] | 1.437 [1.282, 1.611] | 1.953 [1.752, 2.177] | <ā0.001 |
C-reactive protein | 10 mg/L | 1.331 [1.272, 1.393] | 1.623 [1.507, 1.748] | 1(reference) | 1.243 [1.103, 1.400] | 1.562 [1.394, 1.750] | 2.131 [1.909, 2.379] | <ā0.001 |