Table 6 Concentrations of the three anesthetics in different sources of serum and their ratios *

From: A pilot study on LC–MS/MS quantification of remifentanil, etomidate, and rocuronium in maternal and fetal serum microsamples

Serum source

(1)Maternal artery

(2)Umbilical vein

(3)Umbilical artery

Ratio (2)/(1)

Remifentanil (ng/ml)

Mean ± SD

4.75 ± 0.19

2.43 ± 0.13

1.33 ± 0.15

0.52 ± 0.02

Range

2.77 ~ 5.79

1.32 ~ 3.39

0.31 ~ 2.44

0.30 ~ 0.65

Etomidate (ng/ml)

Mean ± SD

412.71 ± 35.29

302.15 ± 29.03

166.24 ± 21.53

0.75 ± 0.04

Range

153.65 ~ 667.81

83.91 ~ 534.32

66.31 ~ 490.44

0.24 ~ 0.97

Rocuronium (μg/ml)

Mean ± SD

7.08 ± 0.48

0.86 ± 0.16

0.44 ± 0.77

0.13 ± 0.02

Range

2.44 ~ 12.30

0.29 ~ 3.73

0.19 ~ 1.44

0.03 ~ 0.47

P

ND

ND

ND

 < 0.001

  1. * From 20 maternal–fetal pairs.
  2. ND, not done.
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