Table 2 Mortality and multivariate Cox regression assessing the association between IBI and incident all-cause and cancer-specific mortality.

From: Inflammatory burden index predicts long term mortality in a nationally representative population from NHANES

Outcomes

Variables

Mortality (%)

Person-years

Incidence/1000 person-years

Hazard ratio (95% CI)

Crude

P value

Model 1

P value

Model 2

P value

All-cause mortality

IBI (Per SD increase)

3483 (23.48)

223719.71

15.57

1.468 (1.406–1.533)

< 0.001

1.276 (1.222–1.331)

< 0.001

1.234 (1.179–1.291)

< 0.001

Quartiles of IBI

 Quartile 1

532 (14.34)

58499.24

9.09

1

 

1

 

1

 

 Quartile 2

858 (23.13)

56319.1

15.23

1.675 (1.471–1.909)

< 0.001

1.128 (0.996–1.279)

0.058

1.116 (0.983–1.268)

0.089

 Quartile 3

1082 (29.16)

54957.25

18.71

2.175 (1.923–2.460)

< 0.001

1.290 (1.144–1.456)

< 0.001

1.244 (1.106-1.400)

< 0.001

 Quartile 4

1065 (28.72)

53944.17

19.74

2.749 (2.414–3.130)

< 0.001

1.689 (1.516–1.881)

< 0.001

1.555 (1.382–1.751)

< 0.001

 P for trend

    

< 0.001

 

< 0.001

 

< 0.001

Cancer mortality

IBI (Per SD increase)

778 (5.24)

223719.71

3.48

1.348 (1.245–1.461)

< 0.001

1.178 (1.081–1.284)

< 0.001

1.141 (1.045–1.246)

0.004

Quartiles of IBI

 Quartile 1

135 (3.64)

58499.24

2.31

1

 

1

 

1

 

 Quartile 2

210 (5.66)

56319.1

3.73

1.501 (1.106–2.037)

0.010

1.059 (0.780–1.439)

0.707

1.018 (0.740–1.402)

0.910

 Quartile 3

212 (5.71)

54957.25

3.86

2.023 (1.469–2.786)

< 0.001

1.288 (0.934–1.778)

0.121

1.214 (0.876–1.682)

0.240

 Quartile 4

221 (5.96)

53944.17

4.10

2.149 (1.651–2.796)

< 0.001

1.420 (1.123–1.797)

0.004

1.295 (1.008–1.662)

0.043

 P for trend

    

< 0.001

 

0.002

 

0.017

  1. Crude: no adjustment; Model 1: adjusted for age, sex, race, current smoking, current drinking, PIR; Model 2: Model 1 + BMI, WC, TC, triglycerides, Scr, hypertension, diabetes, and cancer morbidity.
  2. IBI, inflammatory burden index; CI, confidence interval; SD, standard deviation; BMI, body mass index; WC, waist circumference; TC, total cholesterol; Scr, serum creatinine.