Table 5 Treatment-Related adverse events.
Adverse Events | HAIC group (n = 37) | CisGem group (n = 60) | P value | |||
|---|---|---|---|---|---|---|
Grades 1 and 2 | Grades 3 and 4 | Grades 1 and 2 | Grades 3 and 4 | Any Grade | Grades 3 and 4 | |
Fever | 4 (10.8%) | 0 | 4 (6.7%) | 0 | 0.471 | - |
Abdominal pain | 19 (51.4%) | 6 (16.2%) | 13 (21.7%) | 5 (8.3%) | < 0.001 | 0.234 |
Anorexia | 6 (16.2%) | 1 (2.7%) | 15 (25.0%) | 7 (11.7%) | 0.064 | 0.119 |
Alopecia | 4 (10.8%) | 0 | 3 (5%) | 0 | 0.283 | - |
Nausea | 15 (40.5%) | 1(1.7%) | 38 (63.3%) | 4 (6.7%) | 0.009 | 0.391 |
Vomiting | 12 (32.4%) | 1 (1.7%) | 29 (48.3%) | 9 (15.0%) | 0.007 | 0.053 |
Fatigue | 10 (27.0%) | 1 (2.7%) | 23 (62.2%) | 12 (20%) | 0.006 | 0.015 |
Leukopenia | 5 (18.9%) | 2 (13.5%) | 24 (40.0%) | 10 (16.7%) | < 0.001 | 0.102 |
Thrombocytopenia | 4 (10.8%) | 1 (2.7%) | 17 (28.3%) | 10 (16.7%) | 0.001 | 0.049 |
Anemia | 9 (24.3%) | 1 (2.7%) | 17 (28.3%) | 9 (15.0%) | 0.058 | 0.053 |
Elevated ALT | 5 (13.5%) | 2 (5.4%) | 17 (28.3%) | 9 (15.0%) | 0.013 | 0.148 |
Elevated AST | 14 (37.8%) | 3 (8.1%) | 27 (45.0%) | 3 (5.0%) | 0.698 | 0.537 |
Hyperbilirubinemia | 26 (70.3%) | 1 (2.7%) | 40 (66.7%) | 3 (5.0%) | 0.889 | 0.581 |
Hypoalbuminemia | 6 (16.2%) | 5 (13.5%) | 18 (30.0%) | 20 (33.3%) | 0.001 | 0.030 |
