Fig. 1 | Scientific Reports

Fig. 1

From: Cirsiliol alleviates experimental inflammatory bowel disease via restoration of intestinal barrier integrity and inhibition of NF-κB and MAPK pathways

Fig. 1

Clinical and physiological assessment of normal and DNBS-induced colitis mouse models. (A) Body weight changes: Body weight changes in mice across different treatment groups in the colitis model. The blue line represents the normal group, the red line represents the DNBS-induced colitis mouse model group, the green line represents the DNBS model treated with 10 mg/kg cirsiliol, and the purple line represents the DNBS model treated with 30 mg/kg cirsiliol. (B) Colon length: Measurement of colon length in different groups. (C) Disease Activity Index (DAI) of the four groups. (D-E) HE staining of intestinal tissue and quantitative analysis of Goblet cell percentage. Cir-Low: 10 mg/kg of cirsiliol; Cir-High: 30 mg/kg of cirsiliol. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 indicated statistically significant differences compared to Ethanol 50% group.

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