Table 2 Overlap analysis of DAS genes and ASD-related genes.

From: Prenatal exposure to bisphenol A disrupts RNA splicing in the prefrontal cortex and promotes behaviors related to autism in offspring

Sources (No. of genes)

Both sexes (904)

Males (1794)

Females (1479)

No. of Overlapping genes

p-values

No. of Overlapping genes

p-values

No. of Overlapping genes

p-values

SFARI database

Gene score 1 (234)

20

1.258 × 10−5

28

0.002

26

6.347 × 10−4

Gene score 2 (711)

46

1.727 × 10−5

67

0.002

61

5.513 × 10−4

Gene score 3 (164)

14

0.001

23

5.309 × 10−4

12

0.203

Syndromic genes (301)

24

8.369 × 10−5

38

1.043 × 10−4

32

3.578 × 10−4

Parikshak et al.

(2020)

Frontal and temporal cortex of port-mortem sample (1726)

128

1.038 × 10−17

204

1.693 × 10−16

185

2.103 × 10−18

Cerebellum of port-mortem sample (1590)

109

6.512 × 10−13

162

2.215 × 10−8

159

2.657 × 10−13

Irimia et al.

(2014)

Superior temporal gyrus of port-mortem sample (602)

72

5.594 × 10−21

96

8.489 × 10−16

88

8.903 × 10−17

van de Leemput et al. (2014)

Prefrontal cortex of port-mortem sample (76)

6

0.042

11

0.011

11

0.003

Okay et al.

(2021)

Peripheral Blood Mononuclear Cells (145)

4

0.466

11

0.366

12

0.110

Stamova et al.

(2013)

Peripheral Blood Mononuclear Cells (53)

5

0.032

9

0.008

7

0.027

Peripheral Blood Mononuclear Cells (predicted DAS) (476)

21

0.120

32

0.493

35

0.057

  1. This table shows overlapping DAS genes identified in both sexes, males, and females in the prefrontal cortex of rat offspring prenatally exposed to BPA, compared with autism candidate genes from the SFARI database and DAS genes reported in previous studies. According to SFARI database, gene score 1 = high confidence; 2 = strong candidate; 3 = suggestive evidence.
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