Fig. 6 | Scientific Reports

Fig. 6

From: Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell

Fig. 6

(A) Detecting lactylation of Ku70, Ku80 by Western blots using co-immunoprecipitation (coIP) sample as indicated. (B) Detecting lactylation of Ku70, Ku80 in cells treated with NALA as indicated by Western blot using co-immunoprecipitation (coIP) sample as indicated. (C) Detecting lactylation of Ku70, Ku80 in cells treated with Oxamate or 2-DG as indicated by Western blot. (D) Detecting lactylation of Ku70, Ku80 in cells treated with Oxamate as indicated by Western blot using co-immunoprecipitation (coIP) sample as indicated. (E) Treated with Oxamate or 2-DG significantly affected NHEJ. (F) After treatment with Oxamate or 2-DG, clone formation experiments were conducted to assess the survival rate of A549 cells following different doses of radiotherapy.

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