Table 3 Associations between immune gene expression levels and presence of calcifications or mass among 205 patients in the Carolina Breast Cancer Study and Carolina Mammography Registry.

From: Exploring associations between breast tumor inflammatory gene expression and mammographic calcifications and masses in a community-based population

Immune class

Immune cell type

Gene

Odds Ratio+ (95% Confidence Interval)

Calcification

Mass

Adaptive

B Cell

BLK

0.96 (0.70, 1.33)

1.05 (0.85, 1.29)

CD19

0.85 (0.63, 1.15)

1.19 (0.98, 1.46)

FCRL2

1.26 (0.84, 1.89)

0.97 (0.74, 1.27)

HLA-DOB

1.03 (0.66, 1.64)

1.04 (0.77, 1.40)

KIAA0125

0.82 (0.60, 1.10)

1.08 (0.89, 1.31)

MS4A1

0.96 (0.73, 1.25)

1.04 (0.87, 1.24)

TNFRSF17

0.89 (0.63, 1.25)

0.92 (0.73, 1.15)

Cell Type Score

 

0.94 (0.63, 1.39)

1.07 (0.83, 1.39)

CD8 T Cell

CD8A

1.09 (0.74, 1.59)

0.84 (0.65, 1.07)

Cell Type Score

 

1.09 (0.74, 1.59)

0.84 (0.65, 1.07)

T Cell

CD2

0.80 (0.51, 1.26)

1.05 (0.78, 1.40)

CD246 (CD3Z)

0.82 (0.55, 1.22)

1.14 (0.88, 1.49)

CD28

0.78 (0.48, 1.27)

0.90 (0.65, 1.24)

CD3E

0.85 (0.56, 1.26)

0.96 (0.74, 1.25)

CD3G

0.87 (0.59, 1.28)

0.89 (0.68, 1.14)

CD6

0.73 (0.48, 1.10)

1.36 (1.04, 1.80)

CD96

0.93 (0.60, 1.44)

0.99 (0.74, 1.32)

IL2RB

0.68 (0.45, 1.00)

1.21 (0.94, 1.56)

LCK

0.67 (0.45, 0.97)

1.08 (0.84, 1.39)

SH2D1A

0.77 (0.53, 1.13)

0.87 (0.67, 1.11)

ZAP70

0.81 (0.49, 1.32)

1.15 (0.84, 1.60)

Cell Type Score

 

0.65 (0.35, 1.15)

1.16 (0.80, 1.67)

T Helper Cell

CD4

1.04 (0.65, 1.69)

0.71 (0.51, 0.98)

ICOS

0.88 (0.63, 1.24)

1.02 (0.82, 1.29)

Cell Type Score

 

0.88 (0.53, 1.48)

0.84 (0.59, 1.18)

Tfh

CXCR5 (BLR1)

0.89 (0.62, 1.29)

1.14 (0.90, 1.46)

CXCL13

0.91 (0.72, 1.15)

0.89 (0.76, 1.04)

MAF

1.03 (0.53, 2.05)

0.66 (0.42, 1.04)

PDCD1

0.88 (0.60, 1.29)

1.10 (0.85, 1.42)

SIRPG

0.88 (0.59, 1.31)

1.18 (0.91, 1.54)

Cell Type Score

 

0.78 (0.50, 1.22)

1.05 (0.78, 1.42)

Treg

FOXP3

0.61 (0.39, 0.95)

1.45 (1.05, 2.05)

LAG-3

0.76 (0.49, 1.16)

1.20 (0.90, 1.61)

PD-L1

0.72 (0.44, 1.16)

0.86 (0.62, 1.17)

TIM-3

0.78 (0.46, 1.35)

1.28 (0.89, 1.86)

 

Cell Type Score

 

0.57 (0.30, 1.05)

1.68 (1.11, 2.59)

Innate

Natural Killer Cell

NCR1 (NKP46)

0.66 (0.40, 1.07)

1.09 (0.80, 1.50)

Cell Type Score

 

0.66 (0.40, 1.07)

1.09 (0.80, 1.50)

Eosinophil

CCR3

0.91 (0.70, 1.17)

1.05 (0.89, 1.24)

GPR44

0.89 (0.66, 1.21)

1.04 (0.85, 1.28)

IL5RA

1.03 (0.69, 1.54)

1.21 (0.93, 1.59)

Cell Type Score

 

0.94 (0.68, 1.31)

1.10 (0.89, 1.37)

Macrophage

CCL7

*0.52 (0.35, 0.75)*

*1.48 (1.18, 1.88)*

CD68

0.90 (0.52, 1.51)

1.00 (0.71, 1.41)

CD84

0.85 (0.49, 1.45)

0.97 (0.68, 1.37)

CXCL5

0.72 (0.49, 1.02)

1.18 (0.97, 1.45)

CYBB

0.93 (0.55, 1.60)

0.85 (0.60, 1.22)

FN1

1.32 (0.93, 1.94)

0.75 (0.59, 0.95)

MSR1

1.50 (0.94, 2.44)

0.73 (0.53, 0.99)

PPBP

0.77 (0.52, 1.12)

1.03 (0.81, 1.32)

Cell Type Score

 

1.22 (0.66, 2.25)

0.79 (0.53, 1.18)

Neutrophil

FPRL1

0.97 (0.74, 1.27)

1.01 (0.85, 1.20)

IL8RA

0.92 (0.63, 1.32)

0.95 (0.75, 1.20)

IL8RB

0.94 (0.69, 1.27)

1.02 (0.84, 1.25)

LILRB2

0.68 (0.39, 1.15)

1.26 (0.89, 1.79)

 

Cell Type Score

 

0.88 (0.61, 1.27)

0.96 (0.76, 1.22)

 

Cytotoxic Cells

GZMM

0.78 (0.50, 1.25)

0.95 (0.69, 1.29)

 

PRF1

0.84 (0.49, 1.42)

0.85 (0.60, 1.21)

 

Cell Type Score

 

0.74 (0.88, 1.49)

0.87 (0.59, 1.28)

  1. Bold values correspond to unadjusted p-values < 0.05.
  2. *The Bonferroni-adjusted α was 0.001 for individual genes and 0.005 for cell types. Asterisks indicate confidence intervals where p < adjusted α.
  3. +Odds ratios represent odds of calcification or mass given a one-unit change in log2 gene expression value for a gene or cell type.
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