Table 1 Summary of retention measurements using a set of 140 antibiotics and 421 non-antibiotic drugs. Compounds were classified according to criteria outlined above. MIC values were determined for the 140 antibiotics using MG1655 as wild type E. coli and an isogenic derivative containing a tolC::kan insertion (see Supplementary Table 1 for detailed values). Antibiotic set contains 138 unique drugs and 2 galenic forms of doxycycline and roxithromycin. RP: retention-positive; RN: retention-negative. Nd: not determined. % RP represents the fraction of RP compounds with an MIC in the specified range (≤ 8 µg/mL or larger than 8 µg/mL).
E. coli strain | Known Antibiotics (n = 140) | Drugs (n = 421) | ||
|---|---|---|---|---|
2350 | 2122 | 2350 | 2122 | |
RP | 78 (56%) | 65 (46%) | 127 (30%) | 99 (24%) |
RN | 6 (4%) | 14 (10%) | 98 (23%) | 125 (30%) |
Ambiguous | 9 (6%) | 14 (10%) | 27 (6%) | 30 (7%) |
No/Low Reference | 25/22 (34%) | 98/70 (40%) | ||
% RP (MIC ≤ 8 µg/mL) | 95% | 93% | nd | nd |
% RP (MIC > 8 µg/mL | 85% | 67% | nd | nd |