Fig. 3 | Scientific Reports

Fig. 3

From: Genomic insertion of ancestral uricase into human liver cells to determine metabolic consequences of pseudogenization

Fig. 3

Determining uric acid concentrations. Cells and spheroids were exposed to different uric acid concentrations. AncUOX positive cells or spheroids were able to oxidize uric acid. Both wild-type and control (Puro/RFP only) cells were unable to oxidize uric acid. a–d, Huh monolayer. e–h, Huh spheroids. Values of uric acid are means ± SEM of three replicates. *p < 0.05, **p < 0.01, and ***p < 0.005.

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