Fig. 7 | Scientific Reports

Fig. 7

From: Circ_0008043 promotes the metastasis of hepatocellular carcinoma by regulating the miR-661/PLEKHG4B axis

Fig. 7

ESRP1 promotes the biogenesis of circ_0008043. (A) After shRNAs targeting these splicing factors were transfected into HA22T cells, their expression was measured using qPCR. (B) Effect of splicing factor knockdown on the expression of circ_0008043. (C) The binding sites of ESRP1 in the flanking of circ_0008043. (D) The binding relationship between circ_0008043 and ESRP1 motif was analyzed using RIP. (E) Circ_0008043 expression was measured using qPCR after ESRP1 knockdown when the motif was wild-type or mutated. (F) Effect of ESRP1 knockdown on the expression of circ_0008043 (circPTGR1) and linear PTGR1. **P < 0.01. NS: no significance.

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