Table 2 Heterogeneity and Pleiotropy analyses of the IVW results with p < 0.05.
Exposure | Outcome | Heterogeneity | Pleiotropy | ||
|---|---|---|---|---|---|
Q statistic(IVW) | P value | MR-Egger Intercept | P value | ||
CCL2 | Left ventricular ejection fraction (GCST009395) | 12.84899 | 0.380112 | #N/A | #N/A |
CXCL10 | left ventricular structural | 8.874047 | 0.180786 | -0.00899 | 0.25007 |
CXCL9 | Right ventricular peak atrial filling rate | 6.989999 | 0.429922 | 0.021097 | 0.148165 |
CXCL9 | Left ventricular ejection fraction (GCST90268125) | 5.221955 | 0.632897 | 0.00273 | 0.721321 |
IL-1β | Left ventricular ejection fraction (GCST009395) | #N/A | #N/A | -0.13478 | 0.246983 |
IL-1β | Right ventricular peak atrial filling rate | 4.393823 | 0.355324 | -0.05344 | 0.633607 |
IL-2 | Right ventricular peak ejection rate | 15.62175 | 0.479657 | -0.00377 | 0.970741 |
IL-2 | Left ventricular peak ejection rate | 12.37348 | 0.717895 | 0.023868 | 0.524718 |
IL-5 | Right ventricular stroke volume | 3.070618 | 0.380865 | -0.05231 | 0.25766 |
IL-5 | Right ventricular ejection fraction | 1.807328 | 0.613342 | -0.00059 | 0.216866 |
IL-7 | Right ventricular end diastolic volume | 14.55995 | 0.557073 | 0.060291 | 0.915456 |
IL-7 | Right ventricular stroke volume | 17.80626 | 0.335364 | -1.49548 | 0.24708 |
IL-7 | Left ventricular end diastolic mass | 7.267913 | 0.979807 | -1.22945 | 0.281204 |
IL-7 | Left ventricular end-diastolic volume (GCST90268124) | 9.018566 | 0.939678 | -0.0604 | 0.723395 |
IL-8 | Right ventricular ejection fraction | 12.94179 | 0.531112 | 0.074843 | 0.286839 |
IL-10 | Left ventricular mass to end-diastolic volume ratio | 3.76307 | 0.439019 | 0.000342 | 0.659905 |
IL-18 | Left ventricular ejection fraction (GCST009395) | 20.07187 | 0.217001 | 0.01469 | 0.902915 |
IL-18 | Left ventricular end diastolic mass end diastolic volume ratio | 24.41262 | 0.180798 | -0.11672 | 0.523285 |
IL-18 | Right ventricular peak atrial filling rate | 17.65092 | 0.281462 | -0.02787 | 0.401442 |
IL-18 | Left ventricular peak ejection rate | 11.00676 | 0.685505 | 0.149582 | 0.635638 |
INF-γ | Right ventricular stroke volume | 9.996875 | 0.866791 | -0.31063 | 0.470359 |
INF-γ | Right ventricular ejection fraction | 17.79866 | 0.335818 | 1.124296 | 0.139858 |
INF-γ | Left ventricular peak ejection rate | 13.75236 | 0.617156 | -0.16686 | 0.73127 |
NETs | Left ventricular ejection fraction(GCST009395) | 13.32507 | 0.501102 | 0.021097 | 0.148165 |
Sleep duration | Right ventricular end systolic volume | 86.97399 | 0.042871 | 0.047801 | 0.521244 |
Sleep duration (excluding rs2001329) | Right ventricular end systolic volume | 74.838 | 0.18926 | 0.055866 | 0.550918 |
