Table 3 MR-PRESSO analysis.
Exposure | Outcome | Raw | Outlier corrected | Global P | Number of outliers | Distortion P | ||
|---|---|---|---|---|---|---|---|---|
OR (CI%) | P | OR (CI%) | P | |||||
CCL2 | Left ventricular ejection fraction (GCST009395) | 0.9181 (0.8543–0.9867) | 0.038447 | NA (NA - NA) | NA | 0.366 | NA | NA |
CXCL9 | Right ventricular peak atrial filling rate | 334.3364 (1.9511–57290.0309) | 0.057657 | NA (NA - NA) | NA | 0.531 | NA | NA |
CXCL9 | Left ventricular ejection fraction(GCST90268125) | 1.5249 (1.1594–2.0056) | 0.016603 | NA (NA - NA) | NA | 0.735 | NA | NA |
CXCL10 | left ventricular structural | 1.0043 (1.0006–1.0081) | 0.063205 | NA (NA - NA) | NA | 0.228 | NA | NA |
IL-1β | Left ventricular ejection fraction (GCST009395) | NA (NA - NA) | NA | NA (NA - NA) | NA | 0.859 | NA | NA |
IL-1β | Right ventricular peak atrial filling rate | 3e-04 (0–0.1371) | 0.060824 | NA (NA - NA) | NA | 0.521 | NA | NA |
IL-2 | Right ventricular peak ejection rate | 0.079 (0.0068–0.9169) | 0.059398 | NA (NA - NA) | NA | 0.517 | NA | NA |
IL-2 | Left ventricular peak ejection rate | 0.0594 (0.0056–0.6254) | 0.031888 | NA (NA - NA) | NA | 0.708 | NA | NA |
IL-5 | Right ventricular stroke volume | 1.7737 (0.6577–4.7836) | 0.320823 | NA (NA - NA) | NA | 0.227 | NA | NA |
IL-5 | Right ventricular ejection fraction | 1.2544 (0.8375–1.879) | 0.333186 | NA (NA - NA) | NA | 0.192 | NA | NA |
IL-7 | Left ventricular end diastolic mass | 0.6334 (0.4874–0.8232) | 0.003298 | NA (NA - NA) | NA | 0.978 | NA | NA |
IL-7 | Left ventricular end-diastolic volume (GCST90268124) | 0.4652 (0.2728–0.7933) | 0.012038 | NA (NA - NA) | NA | 0.952 | NA | NA |
IL-7 | Right ventricular stroke volume | 0.5473 (0.336–0.8913) | 0.027657 | NA (NA - NA) | NA | 0.362 | NA | NA |
IL-7 | Right ventricular end diastolic volume | 0.4026 (0.1935–0.8376) | 0.027011 | NA (NA - NA) | NA | 0.593 | NA | NA |
IL-8 | Right ventricular ejection fraction | 1.5396 (1.0953–2.1642) | 0.026277 | NA (NA - NA) | NA | 0.579 | NA | NA |
IL-10 | Left ventricular mass to end-diastolic volume ratio | 1.0908 (1.0106–1.1773) | 0.089418 | NA (NA - NA) | NA | 0.502 | NA | NA |
IL-18 | Left ventricular ejection fraction (GCST009395) | 1.0637 (1.0015–1.1298) | 0.061938 | NA (NA - NA) | NA | 0.231 | NA | NA |
IL-18 | Left ventricular peak ejection rate | 0.0998 (0.0162–0.6136) | 0.024296 | NA (NA - NA) | NA | 0.828 | NA | NA |
IL-18 | Left ventricular end diastolic mass end diastolic volume ratio | 0.9958 (0.9925–0.9992) | 0.024804 | NA (NA - NA) | NA | 0.182 | NA | NA |
IL-18 | Right ventricular peak atrial filling rate | 0.0866 (0.0077–0.9727) | 0.064872 | NA (NA - NA) | NA | 0.378 | NA | NA |
INF-γ | Left ventricular peak ejection rate | 0.0467 (0.0034–0.6324) | 0.034922 | NA (NA - NA) | NA | 0.627 | NA | NA |
INF-γ | Right ventricular ejection fraction | 0.8103 (0.6697–0.9805) | 0.046051 | NA (NA - NA) | NA | 0.337 | NA | NA |
INF-γ | Right ventricular stroke volume | 0.6249 (0.4326–0.9028) | 0.023441 | NA (NA - NA) | NA | 0.869 | NA | NA |
NETs | Left ventricular ejection fraction (GCST009395) | 1.0132 (1.0023–1.0243) | 0.032725 | NA (NA - NA) | NA | 0.502 | NA | NA |
Sleep duration | Right ventricular end systolic volume | 0.0755 (0.0078–0.7288) | 0.028768 | 0.113 (0.0132–0.9673) | 0.050578 | 0.03 | 31 | 0.651 |
Sleep duration (excluding rs2001329) | Right ventricular end systolic volume | 0.113 (0.0132–0.9673) | 0.050578 | NA (NA - NA) | NA | 0.125 | NA | NA |
