Table 1 The differentially expressed genes in different groups.

ENSMUSG00000025082

Up

2.032565173

1.25604E-06

Down

−1.177798237

ENSMUSG00000023886

Up

1.074034671

9.33692E-06

Down

−1.317618818

ENSMUSG00000070304

Up

1.016385679

0.000968225

Down

−1.21956408

ENSMUSG00000033967

Up

1.896671683

7.04983E-05

Down

−1.418756673

ENSMUSG00000022018

Up

1.286232078

5.1858E-07

Down

−2.31953627

ENSMUSG00000029832

Up

1.073536239

0.000980464

Down

−2.254324346

ENSMUSG00000074480

Up

1.142611056

3.84725E-05

Down

−1.281798435

ENSMUSG00000020140

Up

2.394806268

7.63253E-06

Down

−2.75168487

ENSMUSG00000067599

Down

−1.549039945

2.84099E-06

Up

2.182550553

ENSMUSG00000030173

Down

−1.605149914

0.000595382

Up

2.367735049

ENSMUSG00000023132

Down

−1.415938029

0.000192307

Up

2.322406668

ENSMUSG00000017724

Up

2.063394385

1.57123E-06

Down

−3.359791928

ENSMUSG00000047517

Down

−1.043697117

0.000491369

Up

3.166850419

ENSMUSG00000071553

Up

2.12609418

0.000557254

Down

−1.874963419

ENSMUSG00000000318

Down

−1.092390374

0.00018927

Up

1.752234909

ENSMUSG00000025163

Down

−1.793552743

4.3183E-05

Up

1.788178623

ENSMUSG00000062082

Down

−1.114847053

0.000993498

Up

1.324594719

ENSMUSG00000038304

Down

−1.317504254

1.64095E-05

Up

1.379448006

ENSMUSG00000009185

Down

−1.162650035

0.000296416

Up

1.313340437

ENSMUSG00000009248

Up

1.627538099

7.39297E-06

Down

-3.039407405

ENSMUSG00000033576

Down

−1.321414348

0.00029605

Up

3.310710508

ENSMUSG00000021214

Down

−1.982937531

0.000519973

Up

5.337297535

ENSMUSG00000053399

Down

−3.139668325

3.86652E-05

Up

2.808715599

ENSMUSG00000025082

0.001559947

–

0.857028713

0.032169303

ENSMUSG00000023886

2.57316E-12

–

−0.239857515

0.239276579

ENSMUSG00000070304

4.75987E-08

–

−0.203385643

0.384166069

ENSMUSG00000033967

0.000278784

–

0.487436651

0.116502854

ENSMUSG00000022018

4.99616E-30

Down

−1.029214931

1.01677E-05

ENSMUSG00000029832

6.14286E-22

Down

−1.177970938

2.48513E-05

ENSMUSG00000074480

6.76732E-09

–

-0.136410137

0.642423757

ENSMUSG00000020140

5.3495E-40

–

−0.357418938

0.046726629

ENSMUSG00000067599

5.02756E-19

–

0.628550174

0.331722605

ENSMUSG00000030173

1.21963E-07

–

0.761481526

0.3728313

ENSMUSG00000023132

2.04951E-20

–

0.900390529

0.22605681

ENSMUSG00000017724

9.42112E-60

Down

−1.288101348

1.06015E-08

ENSMUSG00000047517

2.19788E-15

Up

2.126222078

4.93154E-05

ENSMUSG00000071553

4.01275E-09

–

0.257604088

0.518340208

ENSMUSG00000000318

1.40318E-10

–

0.659585945

0.036641544

ENSMUSG00000025163

7.2767E-07

–

−0.010669948

0.974912998

ENSMUSG00000062082

3.05705E-07

–

0.20762448

0.56807924

ENSMUSG00000038304

4.1822E-10

–

0.060125304

0.81600711

ENSMUSG00000009185

3.83013E-05

–

0.149856188

0.467550608

ENSMUSG00000009248

4.77142E-13

Down

−1.412030307

3.94524E-05

ENSMUSG00000033576

9.50761E-12

Up

1.991244578

1.87373E-07

ENSMUSG00000021214

4.76818E-11

Up

3.356993285

0.000159069

ENSMUSG00000053399

8.93362E-05

–

−0.338582615

0.734889128

ENSMUSG00000025082

19

56862681

56900510

+

4049

ENSMUSG00000023886

17

14499768

14625052

+

6951

ENSMUSG00000070304

9

45029080

45041368

+

4656

ENSMUSG00000033967

7

12661343

12664999

+

3239

ENSMUSG00000022018

14

79526196

79539085

−

918

ENSMUSG00000029832

6

51409650

51435748

+

2973

ENSMUSG00000074480

3

88439702

88448703

+

5778

ENSMUSG00000020140

10

115286216

115423685

−

10264

ENSMUSG00000067599

6

130195568

130210285

−

1265

ENSMUSG00000030173

6

129875959

129894613

−

1398

ENSMUSG00000023132

13

113230359

113237515

−

1006

ENSMUSG00000017724

11

101660568

101676197

−

3104

ENSMUSG00000047517

7

130633776

130723357

+

7718

ENSMUSG00000071553

6

30541581

30564475

+

3212

ENSMUSG00000000318

11

70047023

70061660

+

2899

ENSMUSG00000025163

11

120927573

120930244

−

1133

ENSMUSG00000062082

16

44632096

44659513

+

2045

ENSMUSG00000038304

3

96706079

96736667

−

2642

ENSMUSG00000009185

11

82006011

82007625

+

511

ENSMUSG00000009248

7

142520566

142523001

−

1623

ENSMUSG00000033576

15

76928929

76941306

+

4498

ENSMUSG00000021214

13

4182614

4200653

−

1207

ENSMUSG00000053399

8

114423758

114575370

−

10178

ENSMUSG00000025082

Vwa2

GO:0005509;GO:0005576;GO:0005604;GO:0005615;GO:0007161;GO:0031012;GO:0042802;GO:0046626;GO:0062023

K24508

–

ENSMUSG00000023886

Smoc2

GO:0005509;GO:0005515;GO:0005539;GO:0005576;GO:0005604;GO:0005614;GO:0005615;GO:0008201;GO:0010595;GO:0010811;GO:0030198;GO:0031012;GO:0035470;GO:0045743;GO:0045766;GO:0045931;GO:0046872;GO:0050840;GO:0062023;GO:0071944;GO:1900748;GO:2000573;GO:2001028

K24354

–

ENSMUSG00000070304

Scn2b

GO:0001518;GO:0005244;GO:0005248;GO:0005272;GO:0005886;GO:0006811;GO:0006814;GO:0007399;GO:0009408;GO:0010467;GO:0016020;GO:0016021;GO:0017080;GO:0030315;GO:0034765;GO:0035725;GO:0046684;GO:0060048;GO:0060371;GO:0061337;GO:0086002;GO:0086006;GO:0086012;GO:0086091;GO:0098915;GO:1902282;GO:2000649

K04846

–

ENSMUSG00000033967

Rnf225

GO:0005575;GO:0016020;GO:0016021;GO:0016567;GO:0046872;GO:0061630

–

–

ENSMUSG00000022018

Rgcc

GO:0000082;GO:0001100;GO:0001818;GO:0001819;GO:0001937;GO:0003331;GO:0005515;GO:0005634;GO:0005654;GO:0005730;GO:0005737;GO:0005813;GO:0005815;GO:0005856;GO:0006956;GO:0007049;GO:0008285;GO:0010628;GO:0010718;GO:0016525;GO:0019901;GO:0030295;GO:0032147;GO:0032967;GO:0043537;GO:0045737;GO:0045840;GO:0045944;GO:0051091;GO:0051496;GO:0051726;GO:0070412;GO:0071456;GO:0072537;GO:0090272;GO:1900087;GO:1901203;GO:1901991;GO:2000048;GO:2000353;GO:2000573

K26108

–

ENSMUSG00000029832

Nfe2l3

GO:0000122;GO:0000978;GO:0000981;GO:0001227;GO:0003677;GO:0003700;GO:0005634;GO:0006355;GO:0006357;GO:0090575

K09040

–

ENSMUSG00000074480

Mex3a

GO:0000932;GO:0003674;GO:0003676;GO:0003723;GO:0005829;GO:0008150;GO:0046872

K15686

EC:2.3.2.27

ENSMUSG00000020140

Lgr5

GO:0001942;GO:0004888;GO:0004930;GO:0005515;GO:0005654;GO:0005794;GO:0005886;GO:0005887;GO:0007165;GO:0007186;GO:0009994;GO:0016020;GO:0016021;GO:0016500;GO:0032588;GO:0042127;GO:0048839;GO:0090263;GO:2001013

K04308

–

ENSMUSG00000067599

Klra7

GO:0005886;GO:0007155;GO:0009897;GO:0016020;GO:0016021;GO:0030246

K24238

–

ENSMUSG00000030173

Klra5

GO:0005886;GO:0007155;GO:0016020;GO:0016021;GO:0030246

-

–

ENSMUSG00000023132

Gzma

GO:0004252;GO:0005576;GO:0005634;GO:0006508;GO:0008233;GO:0008236;GO:0009617;GO:0016787;GO:0019835;GO:0032078;GO:0042803;GO:0043065;GO:0043392;GO:0051354;GO:0051603;GO:0070269;GO:0140507;GO:1902483

K01352

EC:3.4.21.78

ENSMUSG00000017724

Etv4

GO:0000978;GO:0000981;GO:0001228;GO:0003677;GO:0003700;GO:0005634;GO:0005694;GO:0005730;GO:0006355;GO:0006357;GO:0006366;GO:0008045;GO:0010628;GO:0030154;GO:0033600;GO:0043565;GO:0045618;GO:0045893;GO:0045944;GO:0048863;GO:0060444;GO:1990837

K15592

–

ENSMUSG00000047517

Dmbt1

GO:0005044;GO:0005576;GO:0006897;GO:0015031;GO:0016020;GO:0016021;GO:0030154;GO:0110165

K13912

–

ENSMUSG00000071553

Cpa2

GO:0004180;GO:0004181;GO:0005576;GO:0005615;GO:0006508;GO:0008233;GO:0008237;GO:0008270;GO:0016787;GO:0046872

K01298

EC:3.4.17.15

ENSMUSG00000000318

Clec10a

GO:0002248;GO:0009897;GO:0016020;GO:0016021;GO:0030246

K06721

–

ENSMUSG00000025163

Cd7

GO:0002250;GO:0002376;GO:0016020;GO:0016021;GO:0038023;GO:0048873

K06457

–

ENSMUSG00000062082

Cd200r4

GO:0005515;GO:0005886;GO:0009897;GO:0009986;GO:0016020;GO:0016021;GO:0038023;GO:0150077

K21668

–

ENSMUSG00000038304

Cd160

GO:0002250;GO:0002376;GO:0002385;GO:0002729;GO:0002819;GO:0002857;GO:0004888;GO:0005102;GO:0005515;GO:0005576;GO:0005886;GO:0014065;GO:0016020;GO:0016525;GO:0019900;GO:0023024;GO:0031225;GO:0031295;GO:0032393;GO:0032394;GO:0032397;GO:0032729;GO:0043323;GO:0045087;GO:0045954;GO:0046658;GO:0050829;GO:0050860;GO:1900280;GO:1905675;GO:2000353

K06542

–

ENSMUSG00000009185

Ccl8

GO:0002548;GO:0004672;GO:0005125;GO:0005576;GO:0005615;GO:0006816;GO:0006874;GO:0006887;GO:0006935;GO:0006954;GO:0006955;GO:0007165;GO:0007186;GO:0007267;GO:0008009;GO:0008201;GO:0016004;GO:0030593;GO:0031640;GO:0043547;GO:0044828;GO:0045663;GO:0048020;GO:0048245;GO:0048247;GO:0060326;GO:0061844;GO:0070098;GO:0070374;GO:0071346;GO:0071347;GO:0071356;GO:1901741

K16596

–

ENSMUSG00000009248

Ascl2

GO:0000122;GO:0000977;GO:0000978;GO:0000981;GO:0001227;GO:0001666;GO:0001701;GO:0001890;GO:0003677;GO:0003700;GO:0005634;GO:0005737;GO:0006357;GO:0007399;GO:0007423;GO:0010626;GO:0030154;GO:0030182;GO:0035019;GO:0043565;GO:0045944;GO:0046983;GO:0050767;GO:0060708;GO:0060712;GO:0070888;GO:0090575;GO:1990837

K09067

–

ENSMUSG00000033576

Apol6

GO:0003674;GO:0005575;GO:0005576;GO:0006869;GO:0008150;GO:0008289;GO:0016020;GO:0016021;GO:0042157

K14480

–

ENSMUSG00000021214

Akr1c18

GO:0001758;GO:0004032;GO:0004033;GO:0004745;GO:0005634;GO:0005737;GO:0005829;GO:0006693;GO:0006709;GO:0007186;GO:0007565;GO:0007567;GO:0008202;GO:0008284;GO:0010942;GO:0016229;GO:0016488;GO:0016491;GO:0016655;GO:0018636;GO:0032052;GO:0034614;GO:0035410;GO:0042448;GO:0042574;GO:0044597;GO:0044598;GO:0045550;GO:0045703;GO:0047006;GO:0047020;GO:0047023;GO:0047086;GO:0047787;GO:0048385;GO:0050810;GO:0051897;GO:0061370;GO:0071276;GO:0071277;GO:0071372;GO:0071379;GO:0071384;GO:0071394;GO:0071395;GO:0071560;GO:0071799;GO:0097211;GO:1900053;GO:1904322;GO:1990646;GO:2000224;GO:2000353;GO:2000379

K05295

EC:1.1.1.149

ENSMUSG00000053399

Adamts18

GO:0001654;GO:0004222;GO:0005576;GO:0005634;GO:0006508;GO:0008233;GO:0008237;GO:0016787;GO:0030198;GO:0031012;GO:0046872;GO:0090331

K08632

EC:3.4.24.–

ENSMUSG00000025082

T;D

KOG3544;359SZ;39QPM;3BJ7G;3D121;3JDIS;4889C;4935Y;4Q1GH

von Willebrand factor A domain containing 2 [Source:MGI Symbol;Acc:MGI:2684334]

240675

Q70UZ7;Q8CE01

ENSMUSG00000023886

S

KOG4578;35EXC;39SIX;3BCPZ;3CUPY;3J4AW;48APV;4955M;4Q3PM

SPARC related modular calcium binding 2 [Source:MGI Symbol;Acc:MGI:1929881]

64074

Q8CD91

ENSMUSG00000070304

T;P

2R29H;35KKE;38MC8;3BEZ2;3D0AF;3J5SH;488K0;495QK;4PY65

sodium channel, voltage-gated, type II, beta [Source:MGI Symbol;Acc:MGI:106921]

72821

Q56A07;Q1MXF8

ENSMUSG00000033967

O

KOG2177;35FJQ;3A7QW;3BTBD;3D4C1;3J9QG;486K9;497W0;4Q60G

ring finger protein 225 [Source:MGI Symbol;Acc:MGI:1924198]

381845

Q9D7D1

ENSMUSG00000022018

S;K

2S1UB;35PPI;3A3NM;3BRDQ;3D8HJ;3JGF1;48EU0;49BM9;4Q8PZ

regulator of cell cycle [Source:MGI Symbol;Acc:MGI:1913464]

66214

Q9DBX1

ENSMUSG00000029832

K

KOG3863;35MM9;39THC;3BEKZ;3CX4J;3J7TZ;484Z2;48VIJ;4PY0Y

nuclear factor, erythroid derived 2, like 3 [Source:MGI Symbol;Acc:MGI:1339958]

18025

Q9WTM4;Q3UZC1

ENSMUSG00000074480

S;O

KOG2113;3595E;39TJN;3B9BH;3CY96;3J5IM;487YG;496QB;4PZN6

mex3 RNA binding family member A [Source:MGI Symbol;Acc:MGI:1919890]

72640

G3UYU0

ENSMUSG00000020140

T;U

KOG0619;KOG2087;35DDJ;38DRQ;3B9GE;3CSEC;3JBSR;483J8;48Z5S;4PWK2

leucine rich repeat containing G protein coupled receptor 5 [Source:MGI Symbol;Acc:MGI:1341817]

14160

Q9Z1P4

ENSMUSG00000067599

S;T;V

KOG4297;35F8E;3A27M;3BQYM;3D4A6;3J6K3;4887M;4997U;4Q5HW

killer cell lectin-like receptor, subfamily A, member 7 [Source:MGI Symbol;Acc:MGI:101901]

16638

Q60654;F8WJ94

ENSMUSG00000030173

S;T;V

KOG4297;35F8E;3A27M;3BQYM;3D4A6;3J6K3;4887M;4997U;4Q5HW

killer cell lectin-like receptor, subfamily A, member 5 [Source:MGI Symbol;Acc:MGI:101903]

16636

Q60652;Q548A2

ENSMUSG00000023132

O

KOG3627;35AQB;38YQZ;3BDC7;3D50Y;3JDVZ;4874J;48URU;4PW35

granzyme A [Source:MGI Symbol;Acc:MGI:109266]

14938

P11032;Q3U0N0

ENSMUSG00000017724

K

KOG3806;35NXJ;38QW9;3BDHQ;3D2EP;3J4HV;48003;492XC;4Q3KV

ets variant 4 [Source:MGI Symbol;Acc:MGI:99423]

18612

P28322;A6MDC6

ENSMUSG00000047517

S;T;W

2RSDM;39VZN;3BIWA;3E6D2;3JPTT;48RUQ;49N89

deleted in malignant brain tumors 1 [Source:MGI Symbol;Acc:MGI:106210]

12945

Q60997;A0A140LI59

ENSMUSG00000071553

O;E

KOG2650;35CDI;38DUK;3BA6U;3CUQS;3JAWZ;481VD;490AY;4Q6WI

carboxypeptidase A2, pancreatic [Source:MGI Symbol;Acc:MGI:3617840]

232680

Q504N0

ENSMUSG00000000318

S;T;V

KOG4297;35P5C;39YT3;3BMCI;3CVVA;3JAM0;48BF5;48YMK;4Q3MX

C-type lectin domain family 10, member A [Source:MGI Symbol;Acc:MGI:96975]

17312

P49300

ENSMUSG00000025163

S;T

2SD5I;35QB0;3A2S6;3BT2A;3D7HP;3JH0R;48EX6;49BIF;4Q63H

CD7 antigen [Source:MGI Symbol;Acc:MGI:88344]

12516

P50283;Q3U4A8

ENSMUSG00000062082

S;T

2S9IV;35Q1Z;3A2MP;3BR2P;3D278;3J458;488QH;4900F;4Q8NX

CD200 receptor 4 [Source:MGI Symbol;Acc:MGI:3036289]

239849

Q6XJV4

ENSMUSG00000038304

S;T

2RR8D;35PVH;3A0I8;3BQ53;3D6RK;3JGCK;48D6W;49ABT;4Q8T7

CD160 antigen [Source:MGI Symbol;Acc:MGI:1860383]

54215

O88875

ENSMUSG00000009185

–

–

chemokine (C-C motif) ligand 8 [Source:MGI Symbol;Acc:MGI:101878]

20307

Q9Z121;Q149U7

ENSMUSG00000009248

O;K

KOG4029;35VQD;38E2W;3BHUN;3E4DX;3JNJ4;48R3F;49MPF;4Q4C0

achaete-scute family bHLH transcription factor 2 [Source:MGI Symbol;Acc:MGI:96920]

17173

O35885;Q3TJR9

ENSMUSG00000033576

S

2QPNS;35CIJ;3A1BI;3BQ6E;3D1JY;3JF2D;4896G;492TP;4Q54Z

apolipoprotein L 6 [Source:MGI Symbol;Acc:MGI:1919189]

71939

Q3UN08;B7ZC55

ENSMUSG00000021214

S;J;C

KOG1577;35M94;38T1T;3BK9X;3D0AD;3J7EU;4842J;49784;4Q6J6

aldo-keto reductase family 1, member C18 [Source:MGI Symbol;Acc:MGI:2145420]

105349

Q8K023;Q3U538

ENSMUSG00000053399

O

KOG3538;35IXT;38EJ8;3BBR3;3CS90;3JA6A;47Z07;49125;4PUN4

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18 [Source:MGI Symbol;Acc:MGI:2442600]

208936

Q4VC17

ENSMUSG00000025082

GO:0007161//calcium-independent cell-matrix adhesion;GO:0046626//regulation of insulin receptor signaling pathway;

GO:0005576//extracellular region;GO:0005604//basement membrane;GO:0005615//extracellular space;GO:0031012//extracellular matrix;GO:0062023//collagen-containing extracellular matrix;

GO:0005509//calcium ion binding;GO:0042802//identical protein binding;

–

ENSMUSG00000023886

GO:0010595//positive regulation of endothelial cell migration;GO:0010811//positive regulation of cell-substrate adhesion;GO:0030198//extracellular matrix organization;GO:0035470//positive regulation of vascular wound healing;GO:0045743//positive regulation of fibroblast growth factor receptor signaling pathway;GO:0045766//positive regulation of angiogenesis;GO:0045931//positive regulation of mitotic cell cycle;GO:1900748//positive regulation of vascular endothelial growth factor signaling pathway;GO:2000573//positive regulation of DNA biosynthetic process;GO:2001028//positive regulation of endothelial cell chemotaxis;

GO:0005576//extracellular region;GO:0005604//basement membrane;GO:0005614//interstitial matrix;GO:0005615//extracellular space;GO:0031012//extracellular matrix;GO:0062023//collagen-containing extracellular matrix;GO:0071944//cell periphery;

GO:0005509//calcium ion binding;GO:0005515//protein binding;GO:0005539//glycosaminoglycan binding;GO:0008201//heparin binding;GO:0046872//metal ion binding;GO:0050840//extracellular matrix binding;

–

ENSMUSG00000070304

GO:0006811//ion transport;GO:0006814//sodium ion transport;GO:0007399//nervous system development;GO:0009408//response to heat;GO:0010467//gene expression;GO:0034765//regulation of ion transmembrane transport;GO:0035725//sodium ion transmembrane transport;GO:0046684//response to pyrethroid;GO:0060048//cardiac muscle contraction;GO:0060371//regulation of atrial cardiac muscle cell membrane depolarization;GO:0061337//cardiac conduction;GO:0086002//cardiac muscle cell action potential involved in contraction;GO:0086012//membrane depolarization during cardiac muscle cell action potential;GO:0086091//regulation of heart rate by cardiac conduction;GO:0098915//membrane repolarization during ventricular cardiac muscle cell action potential;GO:2000649//regulation of sodium ion transmembrane transporter activity;

GO:0001518//voltage-gated sodium channel complex;GO:0005886//plasma membrane;GO:0016020//membrane;GO:0016021//integral component of membrane;GO:0030315//T-tubule;

GO:0005244//voltage-gated ion channel activity;GO:0005248//voltage-gated sodium channel activity;GO:0005272//sodium channel activity;GO:0017080//sodium channel regulator activity;GO:0086006//voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:1902282//voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;

–

ENSMUSG00000033967

GO:0016567//protein ubiquitination;

GO:0005575//cellular_component;GO:0016020//membrane;GO:0016021//integral component of membrane;

GO:0046872//metal ion binding;GO:0061630//ubiquitin protein ligase activity;

–

ENSMUSG00000022018

GO:0000082//G1/S transition of mitotic cell cycle;GO:0001100//negative regulation of exit from mitosis;GO:0001818//negative regulation of cytokine production;GO:0001819//positive regulation of cytokine production;GO:0001937//negative regulation of endothelial cell proliferation;GO:0003331//positive regulation of extracellular matrix constituent secretion;GO:0006956//complement activation;GO:0007049//cell cycle;GO:0008285//negative regulation of cell population proliferation;GO:0010628//positive regulation of gene expression;GO:0010718//positive regulation of epithelial to mesenchymal transition;GO:0016525//negative regulation of angiogenesis;GO:0032147//activation of protein kinase activity;GO:0032967//positive regulation of collagen biosynthetic process;GO:0043537//negative regulation of blood vessel endothelial cell migration;GO:0045737//positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0045840//positive regulation of mitotic nuclear division;GO:0045944//positive regulation of transcription by RNA polymerase II;GO:0051091//positive regulation of DNA-binding transcription factor activity;GO:0051496//positive regulation of stress fiber assembly;GO:0051726//regulation of cell cycle;GO:0071456//cellular response to hypoxia;GO:0072537//fibroblast activation;GO:0090272//negative regulation of fibroblast growth factor production;GO:1900087//positive regulation of G1/S transition of mitotic cell cycle;GO:1901203//positive regulation of extracellular matrix assembly;GO:1901991//negative regulation of mitotic cell cycle phase transition;GO:2000048//negative regulation of cell-cell adhesion mediated by cadherin;GO:2000353//positive regulation of endothelial cell apoptotic process;GO:2000573//positive regulation of DNA biosynthetic process;

GO:0005634//nucleus;GO:0005654//nucleoplasm;GO:0005730//nucleolus;GO:0005737//cytoplasm;GO:0005813//centrosome;GO:0005815//microtubule organizing center;GO:0005856//cytoskeleton;

GO:0005515//protein binding;GO:0019901//protein kinase binding;GO:0030295//protein kinase activator activity;GO:0070412//R-SMAD binding;

–

ENSMUSG00000029832

GO:0000122//negative regulation of transcription by RNA polymerase II;GO:0006355//regulation of transcription, DNA-templated;GO:0006357//regulation of transcription by RNA polymerase II;

GO:0005634//nucleus;GO:0090575//RNA polymerase II transcription regulator complex;

GO:0000978//RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981//DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227//DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677//DNA binding;GO:0003700//DNA-binding transcription factor activity;

–

ENSMUSG00000074480

GO:0008150//biological_process;

GO:0000932//P-body;GO:0005829//cytosol;

GO:0003674//molecular_function;GO:0003676//nucleic acid binding;GO:0003723//RNA binding;GO:0046872//metal ion binding;

–

ENSMUSG00000020140

GO:0001942//hair follicle development;GO:0007165//signal transduction;GO:0007186//G protein-coupled receptor signaling pathway;GO:0009994//oocyte differentiation;GO:0042127//regulation of cell population proliferation;GO:0048839//inner ear development;GO:0090263//positive regulation of canonical Wnt signaling pathway;GO:2001013//epithelial cell proliferation involved in renal tubule morphogenesis;

GO:0005654//nucleoplasm;GO:0005794//Golgi apparatus;GO:0005886//plasma membrane;GO:0005887//integral component of plasma membrane;GO:0016020//membrane;GO:0016021//integral component of membrane;GO:0032588//trans-Golgi network membrane;

GO:0004888//transmembrane signaling receptor activity;GO:0004930//G protein-coupled receptor activity;GO:0005515//protein binding;GO:0016500//protein-hormone receptor activity;

ko04310(Wnt signaling pathway)

ENSMUSG00000067599

GO:0007155//cell adhesion;

GO:0005886//plasma membrane;GO:0009897//external side of plasma membrane;GO:0016020//membrane;GO:0016021//integral component of membrane;

GO:0030246//carbohydrate binding;

ko04650(Natural killer cell mediated cytotoxicity)

ENSMUSG00000030173

GO:0007155//cell adhesion;

GO:0005886//plasma membrane;GO:0016020//membrane;GO:0016021//integral component of membrane;

GO:0030246//carbohydrate binding;

–

ENSMUSG00000023132

GO:0006508//proteolysis;GO:0009617//response to bacterium;GO:0019835//cytolysis;GO:0032078//negative regulation of endodeoxyribonuclease activity;GO:0043065//positive regulation of apoptotic process;GO:0043392//negative regulation of DNA binding;GO:0051354//negative regulation of oxidoreductase activity;GO:0051603//proteolysis involved in cellular protein catabolic process;GO:0070269//pyroptosis;GO:0140507//granzyme-mediated programmed cell death signaling pathway;GO:1902483//cytotoxic T cell pyroptotic process;

GO:0005576//extracellular region;GO:0005634//nucleus;

GO:0004252//serine-type endopeptidase activity;GO:0008233//peptidase activity;GO:0008236//serine-type peptidase activity;GO:0016787//hydrolase activity;GO:0042803//protein homodimerization activity;

ko04080(Neuroactive ligand-receptor interaction)

ENSMUSG00000017724

GO:0006355//regulation of transcription, DNA-templated;GO:0006357//regulation of transcription by RNA polymerase II;GO:0006366//transcription by RNA polymerase II;GO:0008045//motor neuron axon guidance;GO:0010628//positive regulation of gene expression;GO:0030154//cell differentiation;GO:0033600//negative regulation of mammary gland epithelial cell proliferation;GO:0045618//positive regulation of keratinocyte differentiation;GO:0045893//positive regulation of transcription, DNA-templated;GO:0045944//positive regulation of transcription by RNA polymerase II;GO:0048863//stem cell differentiation;GO:0060444//branching involved in mammary gland duct morphogenesis;

GO:0005634//nucleus;GO:0005694//chromosome;GO:0005730//nucleolus;

GO:0000978//RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981//DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228//DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677//DNA binding;GO:0003700//DNA-binding transcription factor activity;GO:0043565//sequence-specific DNA binding;GO:1990837//sequence-specific double-stranded DNA binding;

ko05202(Transcriptional misregulation in cancer)

ENSMUSG00000047517

GO:0006897//endocytosis;GO:0015031//protein transport;GO:0030154//cell differentiation;

GO:0005576//extracellular region;GO:0016020//membrane;GO:0016021//integral component of membrane;GO:0110165//cellular anatomical entity;

GO:0005044//scavenger receptor activity;

ko04970(Salivary secretion)

ENSMUSG00000071553

GO:0006508//proteolysis;

GO:0005576//extracellular region;GO:0005615//extracellular space;

GO:0004180//carboxypeptidase activity;GO:0004181//metallocarboxypeptidase activity;GO:0008233//peptidase activity;GO:0008237//metallopeptidase activity;GO:0008270//zinc ion binding;GO:0016787//hydrolase activity;GO:0046872//metal ion binding;

ko04974(Protein digestion and absorption);ko04972(Pancreatic secretion)

ENSMUSG00000000318

GO:0002248//connective tissue replacement involved in inflammatory response wound healing;

GO:0009897//external side of plasma membrane;GO:0016020//membrane;GO:0016021//integral component of membrane;

GO:0030246//carbohydrate binding;

–

ENSMUSG00000025163

GO:0002250//adaptive immune response;GO:0002376//immune system process;GO:0048873//homeostasis of number of cells within a tissue;

GO:0016020//membrane;GO:0016021//integral component of membrane;

GO:0038023//signaling receptor activity;

ko04640(Hematopoietic cell lineage)

ENSMUSG00000062082

GO:0150077//regulation of neuroinflammatory response;

GO:0005886//plasma membrane;GO:0009897//external side of plasma membrane;GO:0009986//cell surface;GO:0016020//membrane;GO:0016021//integral component of membrane;

GO:0005515//protein binding;GO:0038023//signaling receptor activity;

ko05167(Kaposi sarcoma-associated herpesvirus infection)

ENSMUSG00000038304

GO:0002250//adaptive immune response;GO:0002376//immune system process;GO:0002385//mucosal immune response;GO:0002729//positive regulation of natural killer cell cytokine production;GO:0002819//regulation of adaptive immune response;GO:0002857//positive regulation of natural killer cell mediated immune response to tumor cell;GO:0014065//phosphatidylinositol 3-kinase signaling;GO:0016525//negative regulation of angiogenesis;GO:0031295//T cell costimulation;GO:0032729//positive regulation of interferon-gamma production;GO:0043323//positive regulation of natural killer cell degranulation;GO:0045087//innate immune response;GO:0045954//positive regulation of natural killer cell mediated cytotoxicity;GO:0050829//defense response to Gram-negative bacterium;GO:0050860//negative regulation of T cell receptor signaling pathway;GO:1900280//negative regulation of CD4-positive, alpha-beta T cell costimulation;GO:1905675//negative regulation of adaptive immune memory response;GO:2000353//positive regulation of endothelial cell apoptotic process;

GO:0005576//extracellular region;GO:0005886//plasma membrane;GO:0016020//membrane;GO:0031225//anchored component of membrane;GO:0046658//anchored component of plasma membrane;

GO:0004888//transmembrane signaling receptor activity;GO:0005102//signaling receptor binding;GO:0005515//protein binding;GO:0019900//kinase binding;GO:0023024//MHC class I protein complex binding;GO:0032393//MHC class I receptor activity;GO:0032394//MHC class Ib receptor activity;GO:0032397//activating MHC class I receptor activity;

–

ENSMUSG00000009185

GO:0002548//monocyte chemotaxis;GO:0006816//calcium ion transport;GO:0006874//cellular calcium ion homeostasis;GO:0006887//exocytosis;GO:0006935//chemotaxis;GO:0006954//inflammatory response;GO:0006955//immune response;GO:0007165//signal transduction;GO:0007186//G protein-coupled receptor signaling pathway;GO:0007267//cell-cell signaling;GO:0030593//neutrophil chemotaxis;GO:0031640//killing of cells of other organism;GO:0043547//positive regulation of GTPase activity;GO:0044828//negative regulation by host of viral genome replication;GO:0045663//positive regulation of myoblast differentiation;GO:0048245//eosinophil chemotaxis;GO:0048247//lymphocyte chemotaxis;GO:0060326//cell chemotaxis;GO:0061844//antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098//chemokine-mediated signaling pathway;GO:0070374//positive regulation of ERK1 and ERK2 cascade;GO:0071346//cellular response to interferon-gamma;GO:0071347//cellular response to interleukin-1;GO:0071356//cellular response to tumor necrosis factor;GO:1901741//positive regulation of myoblast fusion;

GO:0005576//extracellular region;GO:0005615//extracellular space;

GO:0004672//protein kinase activity;GO:0005125//cytokine activity;GO:0008009//chemokine activity;GO:0008201//heparin binding;GO:0016004//phospholipase activator activity;GO:0048020//CCR chemokine receptor binding;

ko04062(Chemokine signaling pathway);ko04061(Viral protein interaction with cytokine and cytokine receptor);ko04060(Cytokine-cytokine receptor interaction)

ENSMUSG00000009248

GO:0000122//negative regulation of transcription by RNA polymerase II;GO:0001666//response to hypoxia;GO:0001701//in utero embryonic development;GO:0001890//placenta development;GO:0006357//regulation of transcription by RNA polymerase II;GO:0007399//nervous system development;GO:0007423//sensory organ development;GO:0010626//negative regulation of Schwann cell proliferation;GO:0030154//cell differentiation;GO:0030182//neuron differentiation;GO:0035019//somatic stem cell population maintenance;GO:0045944//positive regulation of transcription by RNA polymerase II;GO:0050767//regulation of neurogenesis;GO:0060708//spongiotrophoblast differentiation;GO:0060712//spongiotrophoblast layer development;

GO:0005634//nucleus;GO:0005737//cytoplasm;GO:0090575//RNA polymerase II transcription regulator complex;

GO:0000977//RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978//RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981//DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001227//DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003677//DNA binding;GO:0003700//DNA-binding transcription factor activity;GO:0043565//sequence-specific DNA binding;GO:0046983//protein dimerization activity;GO:0070888//E-box binding;GO:1990837//sequence-specific double-stranded DNA binding;

–

ENSMUSG00000033576

GO:0006869//lipid transport;GO:0008150//biological_process;GO:0042157//lipoprotein metabolic process;

GO:0005575//cellular_component;GO:0005576//extracellular region;GO:0016020//membrane;GO:0016021//integral component of membrane;

GO:0003674//molecular_function;GO:0008289//lipid binding;

–

ENSMUSG00000021214

GO:0006693//prostaglandin metabolic process;GO:0006709//progesterone catabolic process;GO:0007186//G protein-coupled receptor signaling pathway;GO:0007565//female pregnancy;GO:0007567//parturition;GO:0008202//steroid metabolic process;GO:0008284//positive regulation of cell population proliferation;GO:0010942//positive regulation of cell death;GO:0016488//farnesol catabolic process;GO:0034614//cellular response to reactive oxygen species;GO:0042448//progesterone metabolic process;GO:0042574//retinal metabolic process;GO:0044597//daunorubicin metabolic process;GO:0044598//doxorubicin metabolic process;GO:0048385//regulation of retinoic acid receptor signaling pathway;GO:0050810//regulation of steroid biosynthetic process;GO:0051897//positive regulation of protein kinase B signaling;GO:0061370//testosterone biosynthetic process;GO:0071276//cellular response to cadmium ion;GO:0071277//cellular response to calcium ion;GO:0071372//cellular response to follicle-stimulating hormone stimulus;GO:0071379//cellular response to prostaglandin stimulus;GO:0071384//cellular response to corticosteroid stimulus;GO:0071394//cellular response to testosterone stimulus;GO:0071395//cellular response to jasmonic acid stimulus;GO:0071560//cellular response to transforming growth factor beta stimulus;GO:0071799//cellular response to prostaglandin D stimulus;GO:0097211//cellular response to gonadotropin-releasing hormone;GO:1900053//negative regulation of retinoic acid biosynthetic process;GO:1904322//cellular response to forskolin;GO:1990646//cellular response to prolactin;GO:2000224//regulation of testosterone biosynthetic process;GO:2000353//positive regulation of endothelial cell apoptotic process;GO:2000379//positive regulation of reactive oxygen species metabolic process;

GO:0005634//nucleus;GO:0005737//cytoplasm;GO:0005829//cytosol;

GO:0001758//retinal dehydrogenase activity;GO:0004032//alditol:NADP+ 1-oxidoreductase activity;GO:0004033//aldo-keto reductase (NADP) activity;GO:0004745//NAD-retinol dehydrogenase activity;GO:0016229//steroid dehydrogenase activity;GO:0016491//oxidoreductase activity;GO:0016655//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor;GO:0018636//phenanthrene 9,10-monooxygenase activity;GO:0032052//bile acid binding;GO:0035410//dihydrotestosterone 17-beta-dehydrogenase activity;GO:0045550//geranylgeranyl reductase activity;GO:0045703//ketoreductase activity;GO:0047006//17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity;GO:0047020//15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity;GO:0047023//androsterone dehydrogenase activity;GO:0047086//ketosteroid monooxygenase activity;GO:0047787//delta4-3-oxosteroid 5beta-reductase activity;

ko00140(Steroid hormone biosynthesis)

ENSMUSG00000053399

GO:0001654//eye development;GO:0006508//proteolysis;GO:0030198//extracellular matrix organization;GO:0090331//negative regulation of platelet aggregation;

GO:0005576//extracellular region;GO:0005634//nucleus;GO:0031012//extracellular matrix;

GO:0004222//metalloendopeptidase activity;GO:0008233//peptidase activity;GO:0008237//metallopeptidase activity;GO:0016787//hydrolase activity;GO:0046872//metal ion binding;

–