Fig. 1 | Scientific Reports

Fig. 1

From: HIF-1α regulates the proliferation and differentiation of mouse cranial base sphenoid-occipital synchondrosis chondrocytes via PI3K/Akt signaling

Fig. 1

The growth pattern of the sphenoid-occipital synchondrosis in 1–8 week-old mice and the expression characteristics of HIF-1α within it. (A) Micro-CT imaging, hematoxylin-eosin (H&E) staining, Safranin O & Fast green staining, and Alcian Blue & Nuclear Fast Red staining reveal the tissue morphological characteristics of the spheno-occipital synchondrosis in 1-8-week-old mice. Scale bar:5 mm、200 μm; (B) IHC staining of HIF-1α in the sphenoid-occipital synchondrosis of 1–8 week-old mice. Scale bar: 200 μm; (C,D) The quantitative expression of positive optical densities in IHC staining using the Image-Pro Plus software. n = 3, *p < 0.05; **p < 0.01; ***p < 0.001;#p < 0.0001;ns: no significance.

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