Table 2 The expected ADME analysis outcomes for substances 4, 6, 8, and 10 compared to forxiga and acarbose.
From: Dual α-amylase and α-glucosidase inhibition by 1,2,4-triazole derivatives for diabetes treatment
Compounds | BBB permeant | GI absorption | Cytochrome P450 (CYP2D6 inhibitor) |
|---|---|---|---|
4 | No | High | Yes |
6 | No | Low | No |
8 | No | Low | No |
10 | No | High | Yes |
Forxiga | No | High | Yes |
Acarbose | No | Low | No |
