Table 3 Univariate and multivariate Cox regression analysis for RFS.
Factor | Category | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
p value | HR | 95% CI | p value | HR | 95% CI | ||
Age | ≥ 70 (vs. < 70 ) | 0.216 | 0.679 | 0.365–1.261 | |||
Sex | Female (vs. Male) | 0.788 | 0.880 | 0.364–2.240 | |||
ASA-PS | 2 or 3 (vs. 0or 1) | 0.619 | 1.205 | 0.577–2.518 | |||
Body Mass Index | ≥ 18.5 (vs. < 18.5) | 0.889 | 1.051 | 0.518–2.134 | |||
Tumor location | Mt or Lt (vs. Ut) | 0.196 | 1.697 | 0.752–3.825 | |||
Clinical tumor depth | cT3 (vs. T1-2) | 0.150 | 0.477 | 0.170–1.341 | |||
Clinical lymph node metastasis | Presence (vs. absence) | 0.297 | 1.412 | 0.735–2.710 | 0.317 | 1.414 | 0.717–2.785 |
Clinical distant meastasis (Supravlavian Lymph node metastases) | Presence (vs. absence) | 0.705 | 1.314 | 0.317–5.450 | |||
Thoracic apprach | OT (vs. MIE) | 0.005* | 2.315 | 1.266–4.237 | 0.018* | 2.096 | 1.138–3.861 |
Variant in ATG2A_R478C | Presence (vs. absence) | 0.025* | 2.469 | 1.085–5.617 | |||
Variant in ULK2_1442-2G > T | Absence (vs. presence) | 0.016* | 2,.331 | 1.147–4.739 | |||
Either presence of variant in ATG2A_R478C or absence of variant in ULK2_1442-2G > T | (vs. Both of absence of variant in ATG2A_R478C and presence of variant in ULK2_1442-2G > T) | 0.016* | 2.331 | 1.146–4.470 | 0.046* | 2.076 | 1.013–4.255 |
