Table 4 Univariate and multivariate Cox regression analysis for OS.
Factor | Category | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
p value | HR | 95% CI | p value | HR | 95% CI | ||
Age | ≥ 70 (vs. < 70 ) | 0.394 | 0.716 | 0.330–1.551 | |||
Sex | Female (vs. Male) | 0.834 | 0.880 | 0.264–2.927 | |||
ASA-PS | 2 or 3 (vs. 0or 1) | 0.302 | 1.651 | 0.636–4.284 | |||
Body Mass Index | ≥ 18.5 (vs. < 18.5) | 0.721 | 0.856 | 0.364–2.014 | |||
Tumor location | Mt or Lt (vs. Ut) | 0.694 | 1.237 | 0.428–3.579 | |||
Clinical tumor depth | cT3 (vs. T1-2) | 0.862 | 1.194 | 0.162–8.819 | |||
Clinical lymph node metastasis | Presence (vs. absence) | 0.077 | 2.210 | 0.896–5.451 | 0.040* | 2.604 | 1.047–6.476 |
Clinical distant metastasis (Supravlavian Lymph node metastases) | Presence (vs. absence) | 0.651 | 1.396 | 0.326–5.969 | |||
Thoracic apprach | OT (vs. MIE) | 0.050 | 2.119 | 0.983–4.566 | 0.212 | 1.650 | 0.751–3.623 |
Variant in ATG2A_R478C | Presence (vs. absence) | 0.002* | 3.741 | 1.494–9.366 | |||
Variant in ULK2_1442-2G > T | Absence (vs. presence) | 0.054 | 2.370 | 0.959–5.848 | |||
Either presence of variant in ATG2A_R478C or absence of variant in ULK2_1442-2G > T | (vs. Both of absence of variant in ATG2A_R478C and presence of variant in ULK2_1442-2G > T) | 0.054 | 2.371 | 0.959–5.860 | 0.029* | 2.764 | 1.109–6.890 |
