Fig. 4
From: CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo
Loss of CAMKKβ has context-dependent effects on disease progression in xenograft models. a Representative images depicting radiance and quantification of total photon flux obtained via in vivo bioluminescence imaging (BLI) of NOD SCID mice intraperitoneally engrafted with firefly luciferase-expressing OVCAR8 parental, OVCAR8 CAMKK2 KO, HeyA8 parental, or HeyA8 CAMKK2 KO cells. b Survival analysis of hosts indicated in (a). For a, data represent mean total photon flux ± SEM for n = 8 (OVCAR8 parental, HeyA8 parental, and HeyA8 CAMKK2 KO) or n = 7 (OVCAR8 CAMKK2 KO) mice. BLI data were analyzed via two-way repeated measures ANOVA (+++p < 0.001) and the Holm-Šídák method was used to compare individual time points (*p < 0.05, **p < 0.01). For b, survival curves were compared using the log-rank test.
