Fig. 1 | Scientific Reports

Fig. 1

From: SKF-38393 regulates the expression of glutamic acid decarboxylase 67 via heparanase-1 in 6-hydroxydopamine-induced neurodegeneration

Fig. 1

Effects of Dopamine Receptor Agonists on Glutamic Acid Decarboxylase 67 and Tyrosine Hydroxylase Expression after 6-Hydroxydopamine Treatment. Western blot analysis was performed to evaluate the expression of glutamic acid decarboxylase 67 (GAD67) and tyrosine hydroxylase (TH) in primary cultured neurons after 6-hydroxydopamine (6-OHDA) treatment. The same analysis was conducted following treatment with dopamine receptor agonists SKF38393 (D1-like receptor agonist) and quinpirole (D2-like receptor agonist). β-actin was used as an internal loading control. Data were expressed as mean ± SD of three independent experiments. ANOVA post hoc was used to calculate statistical significance. *, P < 0.05 compared with the control group; #, P < 0.05 compared with the 6-OHDA group.

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