Fig. 8 | Scientific Reports

Fig. 8

From: Bisphenol A suppresses colon epithelial cell responses via G0/G1-phase arrest, MAPK and PI3K/AKT pathway modulation, and MMP-2/9 Inhibition by upregulating p21WAF1

Fig. 8

p27KIP1 silencing with siRNA had no effect on the BPA-induced colon epithelial cell responses. Colon cells were transfected with either scramble siRNA or p27KIP1 siRNA (si-p27), and then treated with BPA for 24 h. Transfected cells were analyzed by MTT (A) and cell counting assays (B). Wound-healing migration (C) and invasion (D) assays were performed to estimate the metastatic ability using transfected cells. All values from triplicates data are designated as mean ± standard deviation. *p < 0.05 compared with control, #P < 0.05 compared with BPA treatment.

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