Fig. 3 | Scientific Reports

Fig. 3

From: KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling

Fig. 3

ZDHHC8 reduces cisplatin sensitivity in vivo. (a) Images of xenograft tumors generated from CAOV-3 cells with ZDHHC8 knockdown (shZDHHC8) or control (shNC) following treatment with vehicle or CDDP (5 mg/kg, intraperitoneally once weekly for three consecutive weeks). (b) Tumor growth curves of shZDHHC8 CAOV-3 xenografts. (c) Tumor weights of CAOV-3 xenografts were measured at the endpoint of the experiment. (d) Histological analysis of CAOV-3 xenograft tissues using H&E and TUNEL staining. (e) Images of xenograft tumors generated from oeZDHHC8 OVCAR-3 cells. (f) Tumor growth curves of oeZDHHC8 OVCAR-3 xenografts. (g) Tumor weights of OVCAR-3 xenografts were measured at the endpoint of the experiment. (H) H&E and TUNEL staining of OVCAR-3 xenograft tumor tissues.

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