Fig. 5 | Scientific Reports

Fig. 5

From: KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling

Fig. 5

KLF5 reduces chemosensitivity by acting through ZDHHC8. (a) Flow cytometry analysis of CAOV-3 cells after individual or combined knockdown of KLF5 and ZDHHC8 under 10 µM cisplatin (CDDP) treatment. (b) γ-H2AX immunofluorescence staining showing DNA damage in 10 µM CDDP-treated CAOV-3 cells with KLF5 and/or ZDHHC8 knockdown. (c) Flow cytometry analysis of apoptosis in 10 µM CDDP-treated KLF5 knockdown cells with or without ZDHHC8 overexpression. (d) γ-H2AX immunofluorescence staining showing DNA damage in 10 µM CDDP-treated KLF5 knockdown cells with ZDHHC8 overexpression.

Back to article page