Table 4 Evaluation of anti-leishmanial activity of THTT derivatives and Amphotericin B, a standard anti-leishmanial agent, determined across a range of concentrations.

From: Establishment of THTT derivatives as potential antileishmanial and anti-inflammatory agents through in vitro and in silico investigations

Treatment groups

IC50 µM

95% confidence interval

BG

94.1

89.19, 99.02

PG

82.79

80.23, 85.35

T9

20.01

19.36, 20.67

T24

26.94

25.93, 27.95

T25

27.71

27.13, 28.3

Amp-B

15.68

15.44, 15.92

  1. The IC50 (μM) values represent the concentration of each compound required to inhibit 50% of Leishmania parasite growth, with lower values indicating greater anti-leishmanial potency.
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