Table 6 Represents selectivity index (SIc) = CC50/IC50.

From: Establishment of THTT derivatives as potential antileishmanial and anti-inflammatory agents through in vitro and in silico investigations

Treatment groups

SI index (IC50/CC50 µM)

BG

0.25

PG

0.20

T9

0.19

T24

0.25

T25

0.30

Amp-B

0.18

  1. Higher SIc values indicate greater selectivity for the target (e.g., parasites) over host cells (e.g., red blood cells), suggesting a safer and more effective compound. Lower SIc values may indicate potential cytotoxicity or reduced therapeutic window.
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