Fig. 1 | Scientific Reports

Fig. 1

From: Ribosomal protein L5 induces cellular senescence via p53-p21-pRb pathway to mediate relapse of acute myeloid leukemia

Fig. 1

Senescent cell proportion and RPL5 expression levels were elevated in relapsed AML patients. (A) W-G staining and (B) SA-β-gal staining of bone marrow smears from patients with IDA or AML patients across ND, CR, and relapse. (C) Quantification of β-gal-positive senescent cells from (B), expressed as the percentage of positive cells per total counted. Values are means ± SEM, based on ≥ 3 fields per sample. (D) Relative mRNA expression of RPL5 in IDA and AML patients across ND, CR, and relapse phases. Data are shown as mean ± SEM; significance was determined using one-way ANOVA. (E) Western blot of RPL5 protein in paired AML samples from ND, CR, and relapse stages from the same patient; β-actin was used as the loading control. * p < 0.05, ** p < 0.01.

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