Fig. 2 | Scientific Reports

Fig. 2

From: The effect of coadministration of D156844 and AR42 (REC-2282) on the survival and motor phenotype of mice with spinal muscular atrophy

Fig. 2

Oral administration of AR42 augmented the D156844-induced increase in survival of SMNΔ7 SMA mice. Kaplan-Meier survival plot for SMNΔ7 SMA mice receiving either vehicle (dotted blue line; n = 17), 3 mg/kg/d D156844 (solid gray line; n = 13), 10 mg/kg/d AR42 (dashed orange line; n = 16) or a combination of 10 mg/kg/d AR42 and 3 mg/kg/d D156844 (solid brown line; n = 15). Treatment of SMNΔ7 SMA mice began at PND04. All mice within the treatment cohort were maintained on the PicoLab20 diet.

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