Fig. 5 | Scientific Reports

Fig. 5

From: The effect of coadministration of D156844 and AR42 (REC-2282) on the survival and motor phenotype of mice with spinal muscular atrophy

Fig. 5The alternative text for this image may have been generated using AI.

The effect of cotreatment with AR42 and D156844 on surface righting responses of SMNΔ7 SMA mice. SMNΔ7 SMA mice received either 3 mg/kg/d D156844 (gray solid line), 10 mg/kg/d AR42 (orange dashed line, combination of D156844 and AR42 (brown solid line), or vehicle (blue dotted line) beginning at PND04. Behavior responses were also compared against age-matched non-SMA littermates (black solid line). Kaplan-Meier analysis was completed on surface righting success (time-to-event) at PND07 (A) and PND11 (B). The statistical comparisons from the Kaplan-Meier analyses are provided in Table 4.

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