Fig. 6 | Scientific Reports

Fig. 6

From: The effect of coadministration of D156844 and AR42 (REC-2282) on the survival and motor phenotype of mice with spinal muscular atrophy

Fig. 6

The effect of cotreatment with AR42 and D156844 on spontaneous movement responses of SMNΔ7 SMA mice. SMNΔ7 SMA mice received either 3 mg/kg/d D156844 (gray solid line), 10 mg/kg/d AR42 (orange dashed line, combination of D156844 and AR42 (brown solid line), or vehicle (blue dotted line) beginning at PND04. Behavior responses were also compared against age-matched non-SMA littermates (black solid line). Kaplan-Meier analysis was completed on movement success (time-to-event) at PND07 (A), PND11 (B) and PND14 (C). The statistical comparisons from the Kaplan-Meier analyses are provided in Table 5.

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